PERCUTANEOUS ABSORPTION OF SALICYLIC ACID AFTER ADMINISTRATION OF TROLAMINE SALICYLATE CREAM IN RATS WITH TRANSCUTOL ® AND EUCALYPTUS OIL PRE-TREATED SKIN

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SAJJADI PANIZ; KHODAYAR MOHAMMAD JAVAD; SHARIF MAKHMALZADEH BEHZAD; REZAEE SAEED

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Journal: Advanced Pharmaceutical Bulletin Year:2013 | Volume:3 | Issue:2 Page(s): 295-301

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Title

PERCUTANEOUS ABSORPTION OF SALICYLIC ACID AFTER ADMINISTRATION OF TROLAMINE SALICYLATE CREAM IN RATS WITH TRANSCUTOL ® AND EUCALYPTUS OIL PRE-TREATED SKIN

Author(s)

SAJJADI PANIZ | KHODAYAR MOHAMMAD JAVAD | SHARIF MAKHMALZADEH BEHZAD | REZAEE SAEED | Issue Writer Certificate

Keywords

TROLAMINE SALICYLATE

TRANSCUTOL

EUCALYPTUS OIL

TRANSDERMAL ABSORPTION

RAT

NON-LINEAR MIXED EFFECT MODELING

Abstract

Purpose: This study was conducted to assess the effect of skin pre-treatment with TRANSCUTOLÒ and EUCALYPTUS OIL on systemic absorption of topical TROLAMINE SALICYLATE in RAT.Methods: Pharmacokinetic parameters of salicylic acid following administration of TROLAMINE SALICYLATE on RAT skin pre-treated with either TRANSCUTOLÒ or EUCALYPTUS OIL were determined using both non-compartmental and NON-LINEAR MIXED EFFECT MODELING approaches and compared with those of control group.Results: Median (% of interquartile range/median) of salicylic acid AUC0-8hr (ng/mL/hr) values in TRANSCUTOLÒ or EUCALYPTUS OIL treated RATs were 2522 (139%) and 58976 (141%), respectively as compared to the 3023 (327%) of the control group. Skin pre-treatment with EUCALYPTUS OIL could significantly decrease extravascular volume of distribution (V/F) and elimination RATe constant (k) of salicylic acid.Conclusion: Unlike TRANSCUTOLÒ, EUCALYPTUS OIL lead to enhanced TRANSDERMAL ABSORPTION of TROLAMINE SALICYLATE through RAT skin.

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APA: Copy

SAJJADI, PANIZ, KHODAYAR, MOHAMMAD JAVAD, SHARIF MAKHMALZADEH, BEHZAD, & REZAEE, SAEED. (2013). PERCUTANEOUS ABSORPTION OF SALICYLIC ACID AFTER ADMINISTRATION OF TROLAMINE SALICYLATE CREAM IN RATS WITH TRANSCUTOL ^® AND EUCALYPTUS OIL PRE-TREATED SKIN. ADVANCED PHARMACEUTICAL BULLETIN, 3(2), 295-301. SID. https://sid.ir/paper/331802/en

Vancouver: Copy

SAJJADI PANIZ, KHODAYAR MOHAMMAD JAVAD, SHARIF MAKHMALZADEH BEHZAD, REZAEE SAEED. PERCUTANEOUS ABSORPTION OF SALICYLIC ACID AFTER ADMINISTRATION OF TROLAMINE SALICYLATE CREAM IN RATS WITH TRANSCUTOL ^® AND EUCALYPTUS OIL PRE-TREATED SKIN. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2013;3(2):295-301. Available from: https://sid.ir/paper/331802/en

IEEE: Copy

PANIZ SAJJADI, MOHAMMAD JAVAD KHODAYAR, BEHZAD SHARIF MAKHMALZADEH, and SAEED REZAEE, “PERCUTANEOUS ABSORPTION OF SALICYLIC ACID AFTER ADMINISTRATION OF TROLAMINE SALICYLATE CREAM IN RATS WITH TRANSCUTOL ^® AND EUCALYPTUS OIL PRE-TREATED SKIN,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 3, no. 2, pp. 295–301, 2013, [Online]. Available: https://sid.ir/paper/331802/en

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