مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

232
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

150
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

AGGLOMERATION OF CELECOXIB BY QUASI EMULSION SOLVENT DIFFUSION METHOD: EFFECT OF STABILIZER

Pages

  607-616

Abstract

 Purpose: The quasi-emulsion solvent diffusion (QESD) has evolved into an effective technique to manufacture agglomerates of API crystals. Although, the proposed technique showed benefits, such as cost effectiveness, that is considerably sensitive to the choice of a stabilizer, which agonizes from a absence of systemic understanding in this field. In the present study, the combination of different solvents and stabilizers were compared to investigate any connections between the solvents and stabilizers.Methods: Agglomerates of CELECOXIB were prepared by QESD method using four different stabilizers (Tween 80, HPMC, PVP and SLS) and three different solvents (methyl acetate, ethyl acetate and isopropyl acetate). The solid state of obtained particles was investigated by differential scanning calorimetry (DSC) and Fourier transform infrared (FT-IR) spectroscopy. The agglomerated were also evaluated in term of production yield, distribution of particles and dissolution behavior.Results: The results showed that the effectiveness of stabilizer in terms of particle size and particle size distribution is specific to each solvent candidate. A stabilizer with a lower HLB value is preferred which actually increased its effectiveness with the solvent candidates with higher lipophilicity. HPMC appeared to be the most versatile stabilizer because it showed a better stabilizing effect compared to other stabilizers in all solvents used.Conclusion: This study demonstrated that the efficiency of stabilizers in forming the CELECOXIB agglomerates by QESD was influenced by the HLB of the stabilizer and lipophilicity of the solvents.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    MAGHSOODI, MARYAM, & NOKHODCHI, ALI. (2016). AGGLOMERATION OF CELECOXIB BY QUASI EMULSION SOLVENT DIFFUSION METHOD: EFFECT OF STABILIZER. ADVANCED PHARMACEUTICAL BULLETIN, 6(4), 607-616. SID. https://sid.ir/paper/331849/en

    Vancouver: Copy

    MAGHSOODI MARYAM, NOKHODCHI ALI. AGGLOMERATION OF CELECOXIB BY QUASI EMULSION SOLVENT DIFFUSION METHOD: EFFECT OF STABILIZER. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2016;6(4):607-616. Available from: https://sid.ir/paper/331849/en

    IEEE: Copy

    MARYAM MAGHSOODI, and ALI NOKHODCHI, “AGGLOMERATION OF CELECOXIB BY QUASI EMULSION SOLVENT DIFFUSION METHOD: EFFECT OF STABILIZER,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 6, no. 4, pp. 607–616, 2016, [Online]. Available: https://sid.ir/paper/331849/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button