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Information Journal Paper

Title

ANTI-INFLAMMATORY AND ANTIBOTHROPIC PROPERTIES OF JATROPHA ELLIPTICA, A PLANT FROM BRAZILIAN CERRADO BIOME

Pages

  573-579

Abstract

 Purpose: The aim of this study was to evaluate the antibothropic and anti-inflammatory properties of J. elliptica.Methods: Phytochemical screening and thin-layer chromatography (TLC) assays were performed on J. elliptica hydroalcoholic extract (TE) in order to observe its main constituents. The antibothropic activity of TE was evaluated by the in vitro neuromuscular blockade caused by BOTHROPS JARARACUSSU venom (Bjssu), in a mouse phrenic nerve-diaphragm model (PND). A quantitative histological study was carried out to observe a possible protection of TE against the venom myotoxicity. The anti-inflammatory activity was also evaluated in two models, Bjssu-induced paw EDEMA, and carrageenan-induced neutrophils migration in the peritoneal cavity.Results: TLC analysis revealed several compounds in TE, such as saponins, alkaloids, and phenolic constituents. TE was able to neutralize the blockade and the myotoxicity induced by venom, when it was pre-incubated for 30 min with venom. In addition, it showed anti-inflammatory activity, inducing less neutrophils migration and reducing paw EDEMA.Conclusion: J. elliptica showed both antibothropic and anti-inflammatory properties.

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    APA: Copy

    FERREIRA RODRIGUES, SARA COSTA, RODRIGUES, CASSIO MILHOMENS, DOS SANTOS, MARCIO GALDINO, ABRAHAM GAUTUZ, JEAN ANTONIO, GLAUZER SILVA, MAGALI, COGO, JOSE CARLOS, BATISTA SILVA, CAMILA, DOS SANTOS, CLEITON PITA, CARLOS GROPPO, FRANCISCO, COGO MULLER, KARINA, & OSHIMA FRANCO, YOKO. (2016). ANTI-INFLAMMATORY AND ANTIBOTHROPIC PROPERTIES OF JATROPHA ELLIPTICA, A PLANT FROM BRAZILIAN CERRADO BIOME. ADVANCED PHARMACEUTICAL BULLETIN, 6(4), 573-579. SID. https://sid.ir/paper/331853/en

    Vancouver: Copy

    FERREIRA RODRIGUES SARA COSTA, RODRIGUES CASSIO MILHOMENS, DOS SANTOS MARCIO GALDINO, ABRAHAM GAUTUZ JEAN ANTONIO, GLAUZER SILVA MAGALI, COGO JOSE CARLOS, BATISTA SILVA CAMILA, DOS SANTOS CLEITON PITA, CARLOS GROPPO FRANCISCO, COGO MULLER KARINA, OSHIMA FRANCO YOKO. ANTI-INFLAMMATORY AND ANTIBOTHROPIC PROPERTIES OF JATROPHA ELLIPTICA, A PLANT FROM BRAZILIAN CERRADO BIOME. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2016;6(4):573-579. Available from: https://sid.ir/paper/331853/en

    IEEE: Copy

    SARA COSTA FERREIRA RODRIGUES, CASSIO MILHOMENS RODRIGUES, MARCIO GALDINO DOS SANTOS, JEAN ANTONIO ABRAHAM GAUTUZ, MAGALI GLAUZER SILVA, JOSE CARLOS COGO, CAMILA BATISTA SILVA, CLEITON PITA DOS SANTOS, FRANCISCO CARLOS GROPPO, KARINA COGO MULLER, and YOKO OSHIMA FRANCO, “ANTI-INFLAMMATORY AND ANTIBOTHROPIC PROPERTIES OF JATROPHA ELLIPTICA, A PLANT FROM BRAZILIAN CERRADO BIOME,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 6, no. 4, pp. 573–579, 2016, [Online]. Available: https://sid.ir/paper/331853/en

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