مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

236
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

197
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE (TDT) INHIBITION OF CORD BLOOD DERIVED B AND T CELLS EXPANSION

Pages

  215-220

Abstract

 Purpose: Terminal deoxynucleotidyl transferase (TdT) is a DNA polymerase that is present in immature pre-B and pre-T cells. TdT inserts N-nucleotides to the V (D) J gene segment during rearrangements of genes, therefore, it plays a vital role in the development and variation of the immune system in vertebrates. Here we evaluated the relationship between CYTOKINES like interleukin-2 (IL-2), interleukin-7 (IL-7), and interleukin-15 (IL-15) and TdT expression in CORD BLOOD mononuclear cells and also effect of inhibition in the expansion of B AND T CELLS derived from CORD BLOOD.Methodes: The CORD BLOOD mononuclear cells were cultured with different combination of CYTOKINES for 21days, which they were harvested in definite days (7, 14 and 21) and evaluated by flow cytometry.Results: Our data indicated that TdT expression increased in CORD BLOOD mononuclear cells using immune cell key CYTOKINES without being dependent on the type of CYTOKINES. TDT INHIBITION reduced both the expansion of B AND T CELLS derived from CORD BLOOD and also declined the apoptosis and proliferation. Considered together, TdT played an important role in the control of the expansion of B AND T CELLS derived from CORD BLOOD.Conclusion: considered together, it was observed that TdT expression was increased by CYTOKINES and TDT INHIBITION not only reduced B and Tcells derived from CORD BLOOD, but it also affected the rate of apoptosis and proliferation.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    GHOLAMI, SANAZ, MOHAMMADI, SEYEDE MOMENEH, MOVASAGHPOUR AKBARI, ALIAKBAR, ABEDELAHI, ALI, ALIHEMMATI, ALIREZA, FALLAHI, SHIRIN, & NOZAD CHAROUDEH, HOJJATOLLAH. (2017). TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE (TDT) INHIBITION OF CORD BLOOD DERIVED B AND T CELLS EXPANSION. ADVANCED PHARMACEUTICAL BULLETIN, 7(2), 215-220. SID. https://sid.ir/paper/331872/en

    Vancouver: Copy

    GHOLAMI SANAZ, MOHAMMADI SEYEDE MOMENEH, MOVASAGHPOUR AKBARI ALIAKBAR, ABEDELAHI ALI, ALIHEMMATI ALIREZA, FALLAHI SHIRIN, NOZAD CHAROUDEH HOJJATOLLAH. TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE (TDT) INHIBITION OF CORD BLOOD DERIVED B AND T CELLS EXPANSION. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2017;7(2):215-220. Available from: https://sid.ir/paper/331872/en

    IEEE: Copy

    SANAZ GHOLAMI, SEYEDE MOMENEH MOHAMMADI, ALIAKBAR MOVASAGHPOUR AKBARI, ALI ABEDELAHI, ALIREZA ALIHEMMATI, SHIRIN FALLAHI, and HOJJATOLLAH NOZAD CHAROUDEH, “TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE (TDT) INHIBITION OF CORD BLOOD DERIVED B AND T CELLS EXPANSION,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 7, no. 2, pp. 215–220, 2017, [Online]. Available: https://sid.ir/paper/331872/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button