مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

THE FIRST REPORT OF CMY, AAC (6') -IB AND 16S RRNA METHYLASE GENES AMONG PSEUDOMONAS AERUGINOSA ISOLATES FROM IRAN

Pages

  109-112

Abstract

 Background: Serious infections by PSEUDOMONAS AERUGINOSA are commonly treated with the combination of a beta-lactam antibacterial and an aminoglycoside. Therefore, production of a 16S rRNA methylase may result in an extremely important antibacterial resistance profile.Objectives: The present study was conducted to determine the prevalence of Cephamycinase (CMY), aminoglycoside 6' -N-acetyltransferase (aac (6') -Ib) and 16S rRNA methylase genes amongPSEUDOMONAS AERUGINOSA isolates from Iran. Patients and Materials: This descriptive study was performed on hospitalized burnt patients during 2011and 2012. Antibiotics susceptibility tests were performed by disc diffusion and broth microdilution methods. CMY, aac (6') -Ib, 16S rRNA methylase genes were detected by PCR method.Results: Seventy-seven (77%) of 100 isolates were resistant to Imipenem and Ceftazidime. aac (6) -Ib, Cephamycinase (CMY), and rRNA methyltransferase (rmtB and rmtD) were detected in 57 (74.02%), 7 (9.09%), 11 (14.28%), and 9 (11.68%) isolates, respectively. PCR results for aminoglycoside resistance methyltransferase (armA) and rRNA methyltransferase (rmtC) were all negative. Aminoglycoside resistance methyltransferase (armA), and rRNA methyltransferase (rmtC) were not detected.Conclusions: This study detected MULTIPLE DRUG RESISTANCE in PSEUDOMONAS AERUGINOSA including resistance to b-lactams, Aminoglycosides, and Fluoroquinolones. Therefore, identification of DRUG RESISTANCE patterns in P. aeruginosa and detection of panresistant producing isolates are of great importance in prevention and control of infections in burn center ward.

Cites

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    APA: Copy

    JAFARI, MOHSEN, FALLAH, FATEMEH, BORHAN, REBWAR SHAMS, NAVIDINIA, MASOUMEH, KARIMI, ABDOLAH, RAFII TABATABAEI, SEDIGHEH, & HASHEMI, ALI. (2013). THE FIRST REPORT OF CMY, AAC (6') -IB AND 16S RRNA METHYLASE GENES AMONG PSEUDOMONAS AERUGINOSA ISOLATES FROM IRAN. ARCHIVES OF PEDIATRIC INFECTIOUS DISEASES, 1(3), 109-112. SID. https://sid.ir/paper/331945/en

    Vancouver: Copy

    JAFARI MOHSEN, FALLAH FATEMEH, BORHAN REBWAR SHAMS, NAVIDINIA MASOUMEH, KARIMI ABDOLAH, RAFII TABATABAEI SEDIGHEH, HASHEMI ALI. THE FIRST REPORT OF CMY, AAC (6') -IB AND 16S RRNA METHYLASE GENES AMONG PSEUDOMONAS AERUGINOSA ISOLATES FROM IRAN. ARCHIVES OF PEDIATRIC INFECTIOUS DISEASES[Internet]. 2013;1(3):109-112. Available from: https://sid.ir/paper/331945/en

    IEEE: Copy

    MOHSEN JAFARI, FATEMEH FALLAH, REBWAR SHAMS BORHAN, MASOUMEH NAVIDINIA, ABDOLAH KARIMI, SEDIGHEH RAFII TABATABAEI, and ALI HASHEMI, “THE FIRST REPORT OF CMY, AAC (6') -IB AND 16S RRNA METHYLASE GENES AMONG PSEUDOMONAS AERUGINOSA ISOLATES FROM IRAN,” ARCHIVES OF PEDIATRIC INFECTIOUS DISEASES, vol. 1, no. 3, pp. 109–112, 2013, [Online]. Available: https://sid.ir/paper/331945/en

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