مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

CYTOTOXIC AND ANTIOXIDANT ACTIVITY OF A SET OF HETERO BICYLIC METHYLTHIADIAZOLE HYDRAZONES: A STRUCTURE-ACTIVITY STUDY

Pages

  128-137

Abstract

 The current study highlights the in vitro ANTIOXIDANT and antitumor activity of the previously-synthesized hydrazone derivatives against various free radicals and human cancer cell lines, respectively. The ANTICANCER efficacies of the compound were tested by measuring CYTOTOXICITY in cancer cell lines HeLa, A549, and noncancerous NL20 cells. Compounds possessing electron-donor methoxy and methyl substitutions at the para position of the phenyl ring moiety showed a concentration dependent free radical scavenging effects. The free radical-scavenging potential of synthetic compounds 11 and 14 may have significant impact on the prevention of free radical-induced oxidative stress and carcinogenesis. The results from CYTOTOXICITY and cell migration assay showed that the substitution of electron-withdrawing fluoro, chloro and bromo functional groups induced a significant (P<0.001) loss of cell viability and inhibited the invasive potential of the human cancer cells. Additionally, these compounds showed significantly (P<0.05) a less toxicity toward non-cancerous NL20 cells. Docking studies revealed interactions of compound 10 with p38 MAP kinase, which may be responsible of its anti-invasive and anti-proliferative effects.

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    Cite

    APA: Copy

    KODISUNDARAM, PAULRASU, DURAIKANNU, ARUL, BALASANKAR, THIRUNAVUKKARASU, & ROY, KUNAL. (2015). CYTOTOXIC AND ANTIOXIDANT ACTIVITY OF A SET OF HETERO BICYLIC METHYLTHIADIAZOLE HYDRAZONES: A STRUCTURE-ACTIVITY STUDY. INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, 4(2), 128-137. SID. https://sid.ir/paper/332159/en

    Vancouver: Copy

    KODISUNDARAM PAULRASU, DURAIKANNU ARUL, BALASANKAR THIRUNAVUKKARASU, ROY KUNAL. CYTOTOXIC AND ANTIOXIDANT ACTIVITY OF A SET OF HETERO BICYLIC METHYLTHIADIAZOLE HYDRAZONES: A STRUCTURE-ACTIVITY STUDY. INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE[Internet]. 2015;4(2):128-137. Available from: https://sid.ir/paper/332159/en

    IEEE: Copy

    PAULRASU KODISUNDARAM, ARUL DURAIKANNU, THIRUNAVUKKARASU BALASANKAR, and KUNAL ROY, “CYTOTOXIC AND ANTIOXIDANT ACTIVITY OF A SET OF HETERO BICYLIC METHYLTHIADIAZOLE HYDRAZONES: A STRUCTURE-ACTIVITY STUDY,” INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, vol. 4, no. 2, pp. 128–137, 2015, [Online]. Available: https://sid.ir/paper/332159/en

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