مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

ASSOCIATION BETWEEN LONG NONCODING RNA ANRIL EXPRESSION VARIANTS AND SUSCEPTIBILITY TO CORONARY ARTERY DISEASE

Pages

  1-7

Abstract

 Animal cells possess thousands of long non-coding (lnc) RNAs, such as antisense noncoding RNA in the INK4 locus (ANRIL), which have regulatory roles in the cells’ molecular mechanisms, including X-chromosome inactivation, and developmental processes. These lnc RNAs are known to influence the extensive spectrum of agerelated disorders. Accordingly, there is evidence for the role of these lnc RNAs in cardiovascular diseases, particularly CORONARY ARTERY DISEASEs (CAD). The aim of this study was to assess whether the expression of the lnc RNAANRIL was associated with a susceptibility to CAD by evaluating the expression level of the two transcripts of ANRIL. Peripheral blood was taken from fifty patients affected by CAD and relative expression of ANRIL was determined by Real-Time PCR assay. The obtained data indicated that theEU741058 transcript expression level significantly decreased in CAD patients in comparison with the healthy individuals (P=0.001). Furthermore, there was no significant association between theNR_003529 transcript expression, and CAD risk in Iranian patients (P=0.751). Our results suggest that the expression level of theEU741058 transcript of ANRIL may be implicated in CAD development, creating a predictive biomarker for CAD patients in future.

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    APA: Copy

    YARI, MOHSEN, BITARAFAN, SARA, BROUMAND, MOHAMMAD ALI, FAZELI, ZAHRA, rahimi, Mahnoosh, GHADERIAN, SAYYED MOHAMMAD HOSSEIN, MIRFAKHRAIE, REZA, & OMRANI, MIR DAVOOD. (2018). ASSOCIATION BETWEEN LONG NONCODING RNA ANRIL EXPRESSION VARIANTS AND SUSCEPTIBILITY TO CORONARY ARTERY DISEASE. INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, 7(1), 1-7. SID. https://sid.ir/paper/332165/en

    Vancouver: Copy

    YARI MOHSEN, BITARAFAN SARA, BROUMAND MOHAMMAD ALI, FAZELI ZAHRA, rahimi Mahnoosh, GHADERIAN SAYYED MOHAMMAD HOSSEIN, MIRFAKHRAIE REZA, OMRANI MIR DAVOOD. ASSOCIATION BETWEEN LONG NONCODING RNA ANRIL EXPRESSION VARIANTS AND SUSCEPTIBILITY TO CORONARY ARTERY DISEASE. INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE[Internet]. 2018;7(1):1-7. Available from: https://sid.ir/paper/332165/en

    IEEE: Copy

    MOHSEN YARI, SARA BITARAFAN, MOHAMMAD ALI BROUMAND, ZAHRA FAZELI, Mahnoosh rahimi, SAYYED MOHAMMAD HOSSEIN GHADERIAN, REZA MIRFAKHRAIE, and MIR DAVOOD OMRANI, “ASSOCIATION BETWEEN LONG NONCODING RNA ANRIL EXPRESSION VARIANTS AND SUSCEPTIBILITY TO CORONARY ARTERY DISEASE,” INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, vol. 7, no. 1, pp. 1–7, 2018, [Online]. Available: https://sid.ir/paper/332165/en

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