IN SILICO HOMOLOGY MODELING AND EPITOPE PREDICTION OF NADA AS A POTENTIAL VACCINE CANDIDATE IN NEISSERIA MENINGITIDIS

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SHAHSAVANI NARJES; SHEIKHHA MOHAMMAD HASAN; Yousefi Hassan; SEFID FATEMEH

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Journal: International Journal of Molecular and Cellular Medicine Year:2018 | Volume:7 | Issue:1 Page(s): 53-68

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Title

IN SILICO HOMOLOGY MODELING AND EPITOPE PREDICTION OF NADA AS A POTENTIAL VACCINE CANDIDATE IN NEISSERIA MENINGITIDIS

Author(s)

SHAHSAVANI NARJES | SHEIKHHA MOHAMMAD HASAN | Yousefi Hassan | SEFID FATEMEH | Issue Writer Certificate

Keywords

NEISSERIA MENINGITIDIS

NADA

EPITOPE PREDICTION

3D STRUCTURE

Abstract

NEISSERIA MENINGITIDISis a facultative pathogen bacterium which is well founded with a number of adhesion molecules to facilitate its colonization in human nasopharynx track.NEISSERIA MENINGITIDIS is a major cause of mortality from severe meningococcal disease and septicemia.NEISSERIA MENINGITIDIS adhesion, NADA, is a trimeric autotransporter adhesion molecule which is involved in cell adhesion, invasion, and antibody induction. It is identified in approximately 50% ofN. meningitidis isolates, and is established as a vaccine candidate due to its antigenic effects. In the present study, we exploited bioinformatics tools to better understand and determine the 3D STRUCTURE of NADA and its functional residues to select B cell epitopes, and provide information for elucidating the biological function and vaccine efficacy of Nad A. Therefore, this study provided essential data to close gaps existing in biological areas. The most appropriate model of NADA was designed by SWISS MODEL software and important residues were determined using the subsequent epitope mapping procedures. Locations of important linear and conformational epitopes were determined and conserved residues were identified to broaden our knowledge of efficient vaccine design to reduce meningococcal infectioun in population. These data now provide a theme to design more broadly cross-protective antigens.

Cites

In silico Design a vaccine Candidate against Corynebacterium diphtheriae

References

A journey into the brain: insight into how bacterial pathogens cross blood-brain barriers

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APA: Copy

SHAHSAVANI, NARJES, SHEIKHHA, MOHAMMAD HASAN, Yousefi, Hassan, & SEFID, FATEMEH. (2018). IN SILICO HOMOLOGY MODELING AND EPITOPE PREDICTION OF NADA AS A POTENTIAL VACCINE CANDIDATE IN NEISSERIA MENINGITIDIS. INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, 7(1), 53-68. SID. https://sid.ir/paper/332169/en

Vancouver: Copy

SHAHSAVANI NARJES, SHEIKHHA MOHAMMAD HASAN, Yousefi Hassan, SEFID FATEMEH. IN SILICO HOMOLOGY MODELING AND EPITOPE PREDICTION OF NADA AS A POTENTIAL VACCINE CANDIDATE IN NEISSERIA MENINGITIDIS. INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE[Internet]. 2018;7(1):53-68. Available from: https://sid.ir/paper/332169/en

IEEE: Copy

NARJES SHAHSAVANI, MOHAMMAD HASAN SHEIKHHA, Hassan Yousefi, and FATEMEH SEFID, “IN SILICO HOMOLOGY MODELING AND EPITOPE PREDICTION OF NADA AS A POTENTIAL VACCINE CANDIDATE IN NEISSERIA MENINGITIDIS,” INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, vol. 7, no. 1, pp. 53–68, 2018, [Online]. Available: https://sid.ir/paper/332169/en

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