EFFECT OF CONCENTRATED APPLE EXTRACT ON EXPERIMENTAL COLITIS INDUCED BY ACETIC ACID

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PASTRELO MAURICIO MERCALDI; DIAS RIBEIRO CARLA CAROLINE; DUARTE JOSELMO WILLAMYS; BIOAGO GOLLUCKE ANDREA PITELLI; ARTIGIANI NETO RICARDO; ARAKI RIBEIRO DANIEL; MISZPUTEN SENDER JANKIEL; FUJIYAMA OSHIMA CELINA TIZUKO; RIBEIRO PAIOTTI ANA PAULA

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Journal: International Journal of Molecular and Cellular Medicine Year:2017 | Volume:6 | Issue:1 Page(s): 38-49

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Title

EFFECT OF CONCENTRATED APPLE EXTRACT ON EXPERIMENTAL COLITIS INDUCED BY ACETIC ACID

Author(s)

Keywords

EXPERIMENTAL COLITIS

APPLE EXTRACT

ANTIOXIDANT

INOS

CUZNSOD

Abstract

Reactive oxygen and nitrogen species (ROS/RNS) play a crucial role in inflammatory bowel disease (IBD) exacerbating the chronic inflammatory process. Endogenous and diet ANTIOXIDANTs can neutralize these compounds. The apple is widely consumed, with several ANTIOXIDANT activity compounds. The present study evaluated the effects of concentrated APPLE EXTRACT (CAE) in acetic acid induced colitis.29 Wistar male rats were randomized into 5 groups. G1–Sham/saline solution, G2–CAE/control, G3–acetic acid/control, G4–curative-CAE treatment and G5–preventive-CAE treatment. Eight days later, the animals were euthanized and the colonic segment resected for macroscopic and histological analysis. Gene expression was evaluated for inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), catalase and copper and zinc superoxide dismutase (CuZnSOD) by quantitative real time PCR, while protein expression was assessed for INOS, COX-2 and 8-hydroxy-20-deoxyguanosine (8-OHdG) via immunohistochemistry. The groups G3, G4 and G5 had weight loss, while G5 had weight increase at the end of the experiment. The treatment with CAE reduced the macroscopic and microscopic injury, decreased INOS mRNA expression and increased CUZNSOD mRNA expression in animals with induced acetic acid-colitis. The findings of the present study suggest that CAE treatment exerts an ANTIOXIDANT role by downregulating INOS and upregulating CUZNSOD.

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APA: Copy

PASTRELO, MAURICIO MERCALDI, DIAS RIBEIRO, CARLA CAROLINE, DUARTE, JOSELMO WILLAMYS, BIOAGO GOLLUCKE, ANDREA PITELLI, ARTIGIANI NETO, RICARDO, ARAKI RIBEIRO, DANIEL, MISZPUTEN, SENDER JANKIEL, FUJIYAMA OSHIMA, CELINA TIZUKO, & RIBEIRO PAIOTTI, ANA PAULA. (2017). EFFECT OF CONCENTRATED APPLE EXTRACT ON EXPERIMENTAL COLITIS INDUCED BY ACETIC ACID. INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, 6(1), 38-49. SID. https://sid.ir/paper/332180/en

Vancouver: Copy

PASTRELO MAURICIO MERCALDI, DIAS RIBEIRO CARLA CAROLINE, DUARTE JOSELMO WILLAMYS, BIOAGO GOLLUCKE ANDREA PITELLI, ARTIGIANI NETO RICARDO, ARAKI RIBEIRO DANIEL, MISZPUTEN SENDER JANKIEL, FUJIYAMA OSHIMA CELINA TIZUKO, RIBEIRO PAIOTTI ANA PAULA. EFFECT OF CONCENTRATED APPLE EXTRACT ON EXPERIMENTAL COLITIS INDUCED BY ACETIC ACID. INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE[Internet]. 2017;6(1):38-49. Available from: https://sid.ir/paper/332180/en

IEEE: Copy

MAURICIO MERCALDI PASTRELO, CARLA CAROLINE DIAS RIBEIRO, JOSELMO WILLAMYS DUARTE, ANDREA PITELLI BIOAGO GOLLUCKE, RICARDO ARTIGIANI NETO, DANIEL ARAKI RIBEIRO, SENDER JANKIEL MISZPUTEN, CELINA TIZUKO FUJIYAMA OSHIMA, and ANA PAULA RIBEIRO PAIOTTI, “EFFECT OF CONCENTRATED APPLE EXTRACT ON EXPERIMENTAL COLITIS INDUCED BY ACETIC ACID,” INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, vol. 6, no. 1, pp. 38–49, 2017, [Online]. Available: https://sid.ir/paper/332180/en

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