مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

EVALUATION OF PLACENTAL MIR-155-5P AND LONG NON-CODING RNA SONE EXPRESSION IN PATIENTS WITH SEVERE PRE-ECLAMPSIA

Pages

  22-30

Abstract

 It has been well documented that PREECLAMPSIA (PE) has a common etiological background, but little is known about its linkage at the molecular level.Non- coding RNAs are critical posttranscriptional regulators ofgene expression. This study was performed to determine whether PE is associated with alterations in placental noncoding RNAs expression. MicroRNA (miR) -155-5p and long non-coding RNA (lnc) sONE expression, in placentas collected sequentially from 59 patients with PE and 40 normotensive pregnancies were measured using real-time PCR.The relationship between MIR-155-5P andlncsONE expressions was analyzed statistically. MIR-155-5P expression was increased (fold change=1.6, P=0.04), while lncsONE expression was not significantly changed (fold change=1.1, P=0.68), in placentas from patients compared with control group.miR-155-5p was upregulated in placentas from patients with PE and may have influencedeNOS expression. These findings indicate that miRNA-155-5p may be involved in PE pathogenesis and could be a potential biomarker for this disease.

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    APA: Copy

    AZIZI, FAEZEH, SALEH GARGARI, SORAYA, ASADI SHAHMIRZADI, SEDIGHE, DODANGE, FATEMEH, AMIRI, VAHID, MIRFAKHRAIE, REZA, & OMRANI, MIR DAVOOD. (2017). EVALUATION OF PLACENTAL MIR-155-5P AND LONG NON-CODING RNA SONE EXPRESSION IN PATIENTS WITH SEVERE PRE-ECLAMPSIA. INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, 6(1), 22-30. SID. https://sid.ir/paper/332181/en

    Vancouver: Copy

    AZIZI FAEZEH, SALEH GARGARI SORAYA, ASADI SHAHMIRZADI SEDIGHE, DODANGE FATEMEH, AMIRI VAHID, MIRFAKHRAIE REZA, OMRANI MIR DAVOOD. EVALUATION OF PLACENTAL MIR-155-5P AND LONG NON-CODING RNA SONE EXPRESSION IN PATIENTS WITH SEVERE PRE-ECLAMPSIA. INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE[Internet]. 2017;6(1):22-30. Available from: https://sid.ir/paper/332181/en

    IEEE: Copy

    FAEZEH AZIZI, SORAYA SALEH GARGARI, SEDIGHE ASADI SHAHMIRZADI, FATEMEH DODANGE, VAHID AMIRI, REZA MIRFAKHRAIE, and MIR DAVOOD OMRANI, “EVALUATION OF PLACENTAL MIR-155-5P AND LONG NON-CODING RNA SONE EXPRESSION IN PATIENTS WITH SEVERE PRE-ECLAMPSIA,” INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, vol. 6, no. 1, pp. 22–30, 2017, [Online]. Available: https://sid.ir/paper/332181/en

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