Relationship between Single Nucleotide Polymorphisms of GRHL3 and Schizophrenia Susceptibility: A Preliminary Case-Control Study and Bioinformatics Analysis

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SARGAZI SAMAN; Heidari Nia Milad; Sheervalilou Roghayeh; Mirinejad Shekoufeh; Harati Sadegh Mahdiyeh; MOUDI MAHDIYEH; SARAVANI RAMIN; SHAKIBA MANSOOR

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Journal: International Journal of Molecular and Cellular Medicine Year:2020 | Volume:9 | Issue:2 Page(s): 154-164

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Title

Relationship between Single Nucleotide Polymorphisms of GRHL3 and Schizophrenia Susceptibility: A Preliminary Case-Control Study and Bioinformatics Analysis

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Keywords

Bioinformatics

grainyhead-like 3

haplotype

polymorphism

schizophrenia

Abstract

Grainyhead-like (GRHL) transcription factors were recently linked to the etiology of neural tube defects (NTDs). Overlapping patterns in the variation of schizophrenia (SCZ) incidence with that of NTDs suggests the presence of common etiological risk factors. This preliminary study was designed to examine the relationship between two missense variants of GRHL3 gene (rs2486668C/G and rs545809A/T) and SCZ susceptibility among Iranians. Three hundred ninety subjects (192 patients confirmed with SCZ, and 198 healthy controls) were enrolled and genotyped. Statistical and Bioinformatics analyzes were performed to determine the effects of the variants. In silico analyzes were performed to determine the effects of the variants on the secondary structure of GRHL3 protein and prediction of silencer motifs for each variation. Statistically significant differences were observed between the studied groups under codominant AA, dominant AT+AA, and recessive AA genetic contrast models for rs545809A/T. The presence of the A allele of rs545809A/T enhanced SCZ risk by 2. 33 fold. In contrast, rs2486668C/G was not linked to SCZ susceptibility (P > 0. 05). Bioinformatics analysis revealed that both missense SNPs caused substantial changes in the secondary structure of GRHL3-mRNA. Screening of the flanking sequences of rs545809A/T predicted silencer motifs for this SNP. Our results demonstrated that the rs545809A/T of GRHL3 gene could affect the risk of SCZ in Iranian populations. Replication studies are warranted to confirm these results.

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APA: Copy

SARGAZI, SAMAN, Heidari Nia, Milad, Sheervalilou, Roghayeh, Mirinejad, Shekoufeh, Harati Sadegh, Mahdiyeh, MOUDI, MAHDIYEH, SARAVANI, RAMIN, & SHAKIBA, MANSOOR. (2020). Relationship between Single Nucleotide Polymorphisms of GRHL3 and Schizophrenia Susceptibility: A Preliminary Case-Control Study and Bioinformatics Analysis. INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, 9(2), 154-164. SID. https://sid.ir/paper/332293/en

Vancouver: Copy

SARGAZI SAMAN, Heidari Nia Milad, Sheervalilou Roghayeh, Mirinejad Shekoufeh, Harati Sadegh Mahdiyeh, MOUDI MAHDIYEH, SARAVANI RAMIN, SHAKIBA MANSOOR. Relationship between Single Nucleotide Polymorphisms of GRHL3 and Schizophrenia Susceptibility: A Preliminary Case-Control Study and Bioinformatics Analysis. INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE[Internet]. 2020;9(2):154-164. Available from: https://sid.ir/paper/332293/en

IEEE: Copy

SAMAN SARGAZI, Milad Heidari Nia, Roghayeh Sheervalilou, Shekoufeh Mirinejad, Mahdiyeh Harati Sadegh, MAHDIYEH MOUDI, RAMIN SARAVANI, and MANSOOR SHAKIBA, “Relationship between Single Nucleotide Polymorphisms of GRHL3 and Schizophrenia Susceptibility: A Preliminary Case-Control Study and Bioinformatics Analysis,” INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, vol. 9, no. 2, pp. 154–164, 2020, [Online]. Available: https://sid.ir/paper/332293/en

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