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Information Journal Paper

Title

CO-LIQUEFACTION WITH ACETONE AND GC ANALYSIS OF VOLATILE COMPOUNDS IN EXHALED BREATH AS LUNG CANCER BIOMARKERS

Pages

  99-106

Abstract

 Introduction: A simple, rapid and low cost method for enrichment of volatile organic compounds (VOCs) from EXHALED BREATH (EB) is presented.Methods: A 1000 mL home-made extraction device was filled with EB. The VOCs were extracted and condensed in 0.5 mL acetone. Recognition of volatiles in the real studied EB samples was performed by a GC-MS.Results: The method displays an extraction efficiency of>86% with the enrichment factor of 1929 for octanal. Limits of detection and quantification, and linear dynamic range were 0.008, 0.026 and 0.026-400 ng/mL respectively. Analysis of real samples showed the existence of more than 100 compounds in EB of healthy volunteers and patients with LUNG CANCER before and after treatment. Exhaled octanal concentration was significantly higher in LUNG CANCER patient than in healthy volunteers and LUNG CANCER patient after treatment.Conclusion: Having used the proposed approach, high extraction recovery (up to 86%) was attained for the LUNG CANCER marker, octanal, as an important biomarker. Our findings on smaples of EB of healthy controls and patients with LUNG CANCER before and after treatment provide complelling evidence upon the effectiveness of the developed method.

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    APA: Copy

    JOUYBAN, ABOLGHASEM, DJOZAN, DJAVANSHIR, MOHAMMADANDASHTI, PARASTOU, ALIZADEH NABIL, ALI AKBAR, GHORBANPOUR, HOOSHANG, KHOUBNASAB JAFARI, MARYAM, & MOHAMMADZADEH, MOHAMMAD. (2017). CO-LIQUEFACTION WITH ACETONE AND GC ANALYSIS OF VOLATILE COMPOUNDS IN EXHALED BREATH AS LUNG CANCER BIOMARKERS. BIOIMPACTS, 7(2), 99-106. SID. https://sid.ir/paper/334077/en

    Vancouver: Copy

    JOUYBAN ABOLGHASEM, DJOZAN DJAVANSHIR, MOHAMMADANDASHTI PARASTOU, ALIZADEH NABIL ALI AKBAR, GHORBANPOUR HOOSHANG, KHOUBNASAB JAFARI MARYAM, MOHAMMADZADEH MOHAMMAD. CO-LIQUEFACTION WITH ACETONE AND GC ANALYSIS OF VOLATILE COMPOUNDS IN EXHALED BREATH AS LUNG CANCER BIOMARKERS. BIOIMPACTS[Internet]. 2017;7(2):99-106. Available from: https://sid.ir/paper/334077/en

    IEEE: Copy

    ABOLGHASEM JOUYBAN, DJAVANSHIR DJOZAN, PARASTOU MOHAMMADANDASHTI, ALI AKBAR ALIZADEH NABIL, HOOSHANG GHORBANPOUR, MARYAM KHOUBNASAB JAFARI, and MOHAMMAD MOHAMMADZADEH, “CO-LIQUEFACTION WITH ACETONE AND GC ANALYSIS OF VOLATILE COMPOUNDS IN EXHALED BREATH AS LUNG CANCER BIOMARKERS,” BIOIMPACTS, vol. 7, no. 2, pp. 99–106, 2017, [Online]. Available: https://sid.ir/paper/334077/en

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