مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Metformin ameliorates learning and memory deficits in streptozotocin-induced diabetic rats

Pages

  17-22

Abstract

 Background and Objective: Diabetes mellitus (DM) in long-term is associated with Learning and memory decline. Metformin is an anti-diabetic drug with antioxidant and memory-improving effects. Thus, this research study was conducted to assess the effect of Metformin on Learning and memory in diabetic rats. Materials and Methods: In the present study, male Wistar rats (n=32) were randomly assigned to 4 groups: control, control treated with Metformin (200 mg/kg), diabetic, and diabetic treated with Metformin (200 mg/kg). Diabetes was induced by Streptozotocin (STZ) at a dose of 60 mg/kg. Metformin was administered i. p. at a dose of 200 mg/kg one week after STZ injection for 7 weeks. Blood sample was taken from retro-orbital plexus before STZ injection and 4 and 8 weeks after STZ injection to measure blood glucose level. Passive avoidance and Y maze tests were performed to evaluate Learning and memory dysfunctions. Results: After 8 weeks, diabetic rats showed a significant cognitive decline in passive avoidance and Y maze tests that was significantly improved after Metformin treatment. In addition, Metformin exerted a significant hypoglycemic effect in this model of DM. Conclusion: This study clearly showed that treatment with Metformin for 7 weeks could ameliorate cognitive decline in diabetic animals and part of its beneficial effect is due to its hypoglycemic effect.

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    APA: Copy

    Mousavi, Faezeh, EIDI, AKRAM, KHALILI, MOHSEN, & ROGHANI, MEHRDAD. (2018). Metformin ameliorates learning and memory deficits in streptozotocin-induced diabetic rats. JOURNAL OF BASIC & CLINICAL PATHOPHYSIOLOGY, 6(1), 17-22. SID. https://sid.ir/paper/334542/en

    Vancouver: Copy

    Mousavi Faezeh, EIDI AKRAM, KHALILI MOHSEN, ROGHANI MEHRDAD. Metformin ameliorates learning and memory deficits in streptozotocin-induced diabetic rats. JOURNAL OF BASIC & CLINICAL PATHOPHYSIOLOGY[Internet]. 2018;6(1):17-22. Available from: https://sid.ir/paper/334542/en

    IEEE: Copy

    Faezeh Mousavi, AKRAM EIDI, MOHSEN KHALILI, and MEHRDAD ROGHANI, “Metformin ameliorates learning and memory deficits in streptozotocin-induced diabetic rats,” JOURNAL OF BASIC & CLINICAL PATHOPHYSIOLOGY, vol. 6, no. 1, pp. 17–22, 2018, [Online]. Available: https://sid.ir/paper/334542/en

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