Dipeptidyl peptidase-4 inhibitor ameliorates status epilepticus seizures and cognitive disturbances in a rat model of temporal lobe epilepsy

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Jamali raoufi nida; BARATI HOSSEIN; FAHANIK BABAEI JAVAD; BALUCHNEJADMOJARAD TOURANDOKHT

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Basic and Clinical Pathophysiology Year:2018 | Volume:6 | Issue:1 Page(s): 31-36

Download Full-Text

View:

131

Download:

Cites:

Information Journal Paper

Title

Dipeptidyl peptidase-4 inhibitor ameliorates status epilepticus seizures and cognitive disturbances in a rat model of temporal lobe epilepsy

Author(s)

Jamali raoufi nida | BARATI HOSSEIN | FAHANIK BABAEI JAVAD | BALUCHNEJADMOJARAD TOURANDOKHT | Issue Writer Certificate

Keywords

Kainic acid

Linagliptin

Passive avoidance

Y maze

Rat

Abstract

Background and Objective: In temporal lobe epilepsy (TLE), recurrent seizures accompany with cognitive deficit. In some patients, the current medications cannot provide satisfactory control of seizures, therefore new drugs that act through different mechanisms are required. In the present study, the useful effect of dipeptidyl peptidase-4 inhibitor was evaluated in experimental model of temporal lobe epilepsy in male Rats. Materials and Methods: In this study, the effects of administRation of dipeptidyl peptidase-4 inhibitor, Linagliptin, on seizures score according to Racine’ s scores and learning and memory impairment induced by intrahippocampal injection of-maze and Passive avoidance test were studied in Rats. Linagliptin thirty minutes before Kainic acid injection was administRated intracerebroventricularly. Results: In this study, the Kainic acid-induced recurrent seizures, reduced alternation level in Y-maze test (p<0. 001) and lowered step through latency (STL) in the Passive avoidance test (p<0. 001). AdministRation of Linagliptin to epileptic Rats reduced the score of status epilepticus seizures (p<0. 001), increased alternation score (p<0. 05) and learning capability in the Passive avoidance test (p<0. 05). The difference between the effect of valproic acid and Linagliptin on STL and Racine’ s scores was significant (p<0. 05-p<0. 01). Conclusion: The obtained data indicate that Linagliptin in kainate Rats mitigates seizure severity and develops short-term memory.

Cites

No record.

References

No record.

Cite

APA: Copy

Jamali raoufi, nida, BARATI, HOSSEIN, FAHANIK BABAEI, JAVAD, & BALUCHNEJADMOJARAD, TOURANDOKHT. (2018). Dipeptidyl peptidase-4 inhibitor ameliorates status epilepticus seizures and cognitive disturbances in a rat model of temporal lobe epilepsy. JOURNAL OF BASIC & CLINICAL PATHOPHYSIOLOGY, 6(1), 31-36. SID. https://sid.ir/paper/334543/en

Vancouver: Copy

Jamali raoufi nida, BARATI HOSSEIN, FAHANIK BABAEI JAVAD, BALUCHNEJADMOJARAD TOURANDOKHT. Dipeptidyl peptidase-4 inhibitor ameliorates status epilepticus seizures and cognitive disturbances in a rat model of temporal lobe epilepsy. JOURNAL OF BASIC & CLINICAL PATHOPHYSIOLOGY[Internet]. 2018;6(1):31-36. Available from: https://sid.ir/paper/334543/en

IEEE: Copy

nida Jamali raoufi, HOSSEIN BARATI, JAVAD FAHANIK BABAEI, and TOURANDOKHT BALUCHNEJADMOJARAD, “Dipeptidyl peptidase-4 inhibitor ameliorates status epilepticus seizures and cognitive disturbances in a rat model of temporal lobe epilepsy,” JOURNAL OF BASIC & CLINICAL PATHOPHYSIOLOGY, vol. 6, no. 1, pp. 31–36, 2018, [Online]. Available: https://sid.ir/paper/334543/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops