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Information Journal Paper

Title

Salvianolic acid B improves insulin secretion from interleukin 1β-treated rat pancreatic islets: The role of PI3KAkt signaling

Author(s)

 Raoufi Safoura | BALUCHNEJADMOJARAD TOURANDOKHT | Issue Writer Certificate 

Pages

  49-55

Abstract

 Background and Objective: Oxidative stress induced by proinflammatory cytokines such as IL-1β plays a major role in β-cell destruction in diabetes type 1. Salvianolic acid B (Sal B) is a polyphenolic compound with antioxidant and protective effects. Thus, objective of this study was to assess the protection exerted by Sal B on isolated rat islets exposed to IL-1β and to investigate an underlying mechanism in vitro. Materials and Methods: Isolation of Pancreatic islets was done by using the collagenase digestion method. Isolated rat islets were divided into 6 groups including: 1. control, 2. interleukin-1β treated, 3 and 4. interleukin-1β treated+ Sal B, 5 and 6. interleukin-1β treated+ Sal B+ PKB and PI3K inhibitors. Interleukin-1β (1 U/ml) was used to induce cytotoxicity after pretreatment with two doses of Sal B (50 μ M and 100 μ M) and application of each inhibitors was before Sal B. Results: IL-1β significantly decreased Insulin secretion from isolated islets. Pretreatment with Sal B ameliorated the effect of IL-1β on glucose stimulated Insulin secretion in a concentration dependent manner. Inhibitors of PKB and PI3K both abolished these improving effect of Sal B. Conclusion: Sal B that has antioxidant, anti inflammatory and anti apoptotic properties, provided resistance to pancreatic β-cell dysfunction from cytokine in part via PI3K/Akt pathway. The findings represent that it is a promising agent for prevention of β-cell dysfunction in type 1 diabetes.

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    • Cite

    APA: Copy

    Raoufi, Safoura, & BALUCHNEJADMOJARAD, TOURANDOKHT. (2018). Salvianolic acid B improves insulin secretion from interleukin 1β-treated rat pancreatic islets: The role of PI3KAkt signaling. JOURNAL OF BASIC & CLINICAL PATHOPHYSIOLOGY, 6(1), 49-55. SID. https://sid.ir/paper/334546/en

    Vancouver: Copy

    Raoufi Safoura, BALUCHNEJADMOJARAD TOURANDOKHT. Salvianolic acid B improves insulin secretion from interleukin 1β-treated rat pancreatic islets: The role of PI3KAkt signaling. JOURNAL OF BASIC & CLINICAL PATHOPHYSIOLOGY[Internet]. 2018;6(1):49-55. Available from: https://sid.ir/paper/334546/en

    IEEE: Copy

    Safoura Raoufi, and TOURANDOKHT BALUCHNEJADMOJARAD, “Salvianolic acid B improves insulin secretion from interleukin 1β-treated rat pancreatic islets: The role of PI3KAkt signaling,” JOURNAL OF BASIC & CLINICAL PATHOPHYSIOLOGY, vol. 6, no. 1, pp. 49–55, 2018, [Online]. Available: https://sid.ir/paper/334546/en

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