RADIO-PROTECTIVE EFFECTS OF SOME BIS- THIOSEMICARBAZONE COMPOUNDS

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SHIRAZI A.R.; MEHDIPOUR Z.; JALILIAN A.R.; MIHANDOOST E.

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Journal Paper

Paper Information

Journal: JOURNAL OF BIOMEDICAL PHYSICS AND ENGINEERING Year:2012 | Volume:2 | Issue:1 Page(s): 31-36

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Information Journal Paper

Title

RADIO-PROTECTIVE EFFECTS OF SOME BIS- THIOSEMICARBAZONE COMPOUNDS

Author(s)

SHIRAZI A.R. | MEHDIPOUR Z. | JALILIAN A.R. | MIHANDOOST E. | Issue Writer Certificate

Keywords

RADIO-PROTECTIVE AGENTS

ATSM

PTSM

GTS

AST

ALT

Abstract

Background: GTS, PTSM and ATSM are bis-thiosemicarbazone ligands used in the preparation of copper radiopharmaceuticals. Chemical structure of these materials indicates that they should have radio-protective effects. Objective: To study the radio-protective effects of GTS, PTSM and ATSM. Methods: This study has focused on radio-protective effects of these compounds at different doses (20, 40 and 80 mg) and with time intervals of 1 and 4 h before the whole-body gamma-irradiation. The survival curves were plotted for different groups after one month post-irradiation. The effective doses of these compounds were also calculated from the survival study. In the next step, biochemical markers of hepatic function, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were determined in a hepatotoxicity study. Results: Administration of ATSM did not cause any serious side effects and hepatotoxicity in a mice model-AST and ALT enzyme levels in a group of animals that received 80 mg of ATSM showed no significant difference with that in the control group. However, AST and ALT enzymes rose significantly in those mice that received 40 mg of GTS compared to the control group even 7 days post-injection. Conclusion: It seems that ATSM is a better candidate on which to carry out further research for protection against irradiation.

Cites

EVALUATION OF RADIO-PROTECTIVE EFFECT OF MELATONIN ON WHOLE BODY IRRADIATION INDUCED LIVER TISSUE DAMAGE

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APA: Copy

SHIRAZI, A.R., MEHDIPOUR, Z., JALILIAN, A.R., & MIHANDOOST, E.. (2012). RADIO-PROTECTIVE EFFECTS OF SOME BIS- THIOSEMICARBAZONE COMPOUNDS. JOURNAL OF BIOMEDICAL PHYSICS AND ENGINEERING, 2(1), 31-36. SID. https://sid.ir/paper/334581/en

Vancouver: Copy

SHIRAZI A.R., MEHDIPOUR Z., JALILIAN A.R., MIHANDOOST E.. RADIO-PROTECTIVE EFFECTS OF SOME BIS- THIOSEMICARBAZONE COMPOUNDS. JOURNAL OF BIOMEDICAL PHYSICS AND ENGINEERING[Internet]. 2012;2(1):31-36. Available from: https://sid.ir/paper/334581/en

IEEE: Copy

A.R. SHIRAZI, Z. MEHDIPOUR, A.R. JALILIAN, and E. MIHANDOOST, “RADIO-PROTECTIVE EFFECTS OF SOME BIS- THIOSEMICARBAZONE COMPOUNDS,” JOURNAL OF BIOMEDICAL PHYSICS AND ENGINEERING, vol. 2, no. 1, pp. 31–36, 2012, [Online]. Available: https://sid.ir/paper/334581/en

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