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Information Journal Paper

Title

Magnetic Resonance Imaging Property of Doxorubicin-Loaded Gadolinium/13X Zeolite/Folic Acid Nanocomposite

Pages

  103-110

Abstract

 Background: Magnetic Resonance Imaging (MRI) using nanostructures has been a proper method for tumor targeting purposes. Different MRI nanomaterials, targeting agents and anticancer drugs have been used for targeting of tumors. Objectives: This study aims to consider the MRI property of Doxorubicin (DOX)-loaded Gadolinium/13X zeolite/Folic Acid (Gd3+/13X/FA) nanocomposite. Material and Methods: In this in vitro study, Gd3+/13X/FA/DOX nanocomposite was prepared and the X-ray diffraction, scanning electron microscopy and MTT assay were conducted to evaluate the physicochemical properties of the nanocomposite. MRI was performed at 25° C using a 1. 5 T clinical system to determine the T1 relaxation times and subsequently, the T1 Relaxivity. Results: The size of the nanocomposite was in the range of 80-200 nm. The nanocomposite without DOX loading (Gd3+/13X/FA) showed compatibility for A549 cells for all concentrations while DOX-loaded nanocomposite was toxic for 62% of the cells at the concentration of 0. 4 mg/ml. The T1 Relaxivity of Gd3+/13X/FA/DOX nanocomposite was 4. 0401 mM-1s-1. Conclusion: Gd3+/13X/FA/DOX nanocomposite shows a T1 Relaxivity similar to the conventional Gadolinium chelates, and a successful DOX loading.

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    APA: Copy

    GHADERI, S., Divband, B., & GHAREHAGHAJI, N.. (2020). Magnetic Resonance Imaging Property of Doxorubicin-Loaded Gadolinium/13X Zeolite/Folic Acid Nanocomposite. JOURNAL OF BIOMEDICAL PHYSICS AND ENGINEERING, 10(1), 103-110. SID. https://sid.ir/paper/334727/en

    Vancouver: Copy

    GHADERI S., Divband B., GHAREHAGHAJI N.. Magnetic Resonance Imaging Property of Doxorubicin-Loaded Gadolinium/13X Zeolite/Folic Acid Nanocomposite. JOURNAL OF BIOMEDICAL PHYSICS AND ENGINEERING[Internet]. 2020;10(1):103-110. Available from: https://sid.ir/paper/334727/en

    IEEE: Copy

    S. GHADERI, B. Divband, and N. GHAREHAGHAJI, “Magnetic Resonance Imaging Property of Doxorubicin-Loaded Gadolinium/13X Zeolite/Folic Acid Nanocomposite,” JOURNAL OF BIOMEDICAL PHYSICS AND ENGINEERING, vol. 10, no. 1, pp. 103–110, 2020, [Online]. Available: https://sid.ir/paper/334727/en

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