Local Xenotransplantation of Bone Marrow Derived Mast Cells (BMMCs) Improves Functional Recovery of Transected Sciatic Nerve in Cat: A Novel Approach in Cell Therapy

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MOHAMMADI RAHIM; Anousheh Dana; Alaei Mohammad Hazhir; Nikpasand Amin; Rostami Hawdam; SHAHROOZ RASOUL

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Journal Paper

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Journal: Bulletin of Emergency And Trauma Year:2018 | Volume:6 | Issue:2 Page(s): 108-114

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Title

Local Xenotransplantation of Bone Marrow Derived Mast Cells (BMMCs) Improves Functional Recovery of Transected Sciatic Nerve in Cat: A Novel Approach in Cell Therapy

Author(s)

Keywords

Sciatic nerve

Mast cells

Biomechanical properties

Cats

Abstract

Objective: To determine the effects of bone marrow derived Mast cells (BMMCs) on functional recovery of transected Sciatic nerve in animal model of cat. Method: A 20-mm Sciatic nerve defect was bridged using a silicone nerve guide filled with BMMCs in BMMC group. In Sham-surgery group (SHAM), the Sciatic nerve was only exposed and manipulated. In control group (SILOCONE) the gap was repaired with a silicone nerve guide and both ends were sealed using sterile Vaseline to avoid leakage and the nerve guide was filled with 100 μ L of phosphate-buffered saline alone. In cell treated group ([SILOCONE/BMMC) the nerve guide was filled with 100 μ L BMMCs (2× 106 cells/100 μ L). The regenerated nerve fibers were studied, biomechanically, histologically and immunohiscochemically 6 months later. Results: Biomechanical studies confirmed faster recovery of regenerated axons in BMMCs transplanted animals compared to control group (p<0. 05). Morphometric indices of the regenerated fibers showed that the number and diameter of the myelinated fibers were significantly higher in BMMCs transplanted animals than in control group (p<0. 05). In immunohistochemistry, location of reactions to S-100 in BMMCs transplanted animals was clearly more positive than that in control group. Conclusion: BMMCs xenotransplantation could be considered as a readily accessible source of cells that could improve recovery of transected Sciatic nerve.

Cites

Effect of Local Administration of Verapamil Combined with Chitosan Based Hybrid Nanofiber Conduit on Transected Sciatic Nerve in Rat

References

Mast cells improve functional recovery of transected peripheral nerve: A novel preliminary study

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APA: Copy

MOHAMMADI, RAHIM, Anousheh, Dana, Alaei, Mohammad Hazhir, Nikpasand, Amin, Rostami, Hawdam, & SHAHROOZ, RASOUL. (2018). Local Xenotransplantation of Bone Marrow Derived Mast Cells (BMMCs) Improves Functional Recovery of Transected Sciatic Nerve in Cat: A Novel Approach in Cell Therapy. BULLETIN OF EMERGENCY AND TRAUMA BEAT, 6(2), 108-114. SID. https://sid.ir/paper/335085/en

Vancouver: Copy

MOHAMMADI RAHIM, Anousheh Dana, Alaei Mohammad Hazhir, Nikpasand Amin, Rostami Hawdam, SHAHROOZ RASOUL. Local Xenotransplantation of Bone Marrow Derived Mast Cells (BMMCs) Improves Functional Recovery of Transected Sciatic Nerve in Cat: A Novel Approach in Cell Therapy. BULLETIN OF EMERGENCY AND TRAUMA BEAT[Internet]. 2018;6(2):108-114. Available from: https://sid.ir/paper/335085/en

IEEE: Copy

RAHIM MOHAMMADI, Dana Anousheh, Mohammad Hazhir Alaei, Amin Nikpasand, Hawdam Rostami, and RASOUL SHAHROOZ, “Local Xenotransplantation of Bone Marrow Derived Mast Cells (BMMCs) Improves Functional Recovery of Transected Sciatic Nerve in Cat: A Novel Approach in Cell Therapy,” BULLETIN OF EMERGENCY AND TRAUMA BEAT, vol. 6, no. 2, pp. 108–114, 2018, [Online]. Available: https://sid.ir/paper/335085/en

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