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Information Journal Paper

Title

Interaperitoneal Administration of Α lpha-Tocopherol Loaded Nanoparticles Improves Ischemia-Reperfusion Injury in Rat Ovaries Torsion and Detorsion Model

Pages

  207-216

Abstract

 Objective: To investigate effects of Intraperitoneally administration of α;-tocopherol loaded nanoparticles (TNP) on Ischemia-reperfusion injury in ovaries. Methods: Thirty-five healthy female Wistar rats ~250g were randomized into seven experimental groups (n=5): Group SHAM: The rats underwent only laparotomy. Group Ischemia: A 3-hour ischemia only. Group I/R: A 3-hour ischemia and a 3-hour reperfusion. Group I/T: A 3-hour ischemia only and 100 mg/kg Intraperitoneal administration (IP) of α;-tocopherol 2. 5 hours after induction of ischemia. Group I/R/T: A 3-hour ischemia, a 3-hour reperfusion and 100 mg/kg IP of α;-tocopherol 2. 5 hours after induction of ischemia. Group I/TNP: A 3-hour ischemia only and 1 mg/kg IP of TNP 2. 5 hours after induction of ischemia. Group I/R/TNP: A 3-hour ischemia, a 3-hour reperfusion and 1 mg/kg IP of TNP 2. 5 hours after induction of ischemia. Results: Animals treated with α; TNP showed significantly ameliorated development of ischemia and reperfusion tissue injury compared to those of other groups (p=0. 001). The significant higher values of SOD, tGSH, GPO, GSHRd and GST were observed in I/R/NC animals compared to those of other groups (p=0. 001). Damage indicators (NOS, MDA, MPO and DNA damage level) were significantly lower in I/R/NC animal compared to those of other groups (p=0. 001). Conclusion: Intraperitoneal administration of TNP could be helpful in minimizing Ischemia-reperfusion injury in ovarian tissue exposed to ischemia.

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    APA: Copy

    NAJAFPOUR, ALIREZA, & Azizizadeh, Houman. (2018). Interaperitoneal Administration of Α lpha-Tocopherol Loaded Nanoparticles Improves Ischemia-Reperfusion Injury in Rat Ovaries Torsion and Detorsion Model. BULLETIN OF EMERGENCY AND TRAUMA BEAT, 6(3), 207-216. SID. https://sid.ir/paper/335129/en

    Vancouver: Copy

    NAJAFPOUR ALIREZA, Azizizadeh Houman. Interaperitoneal Administration of Α lpha-Tocopherol Loaded Nanoparticles Improves Ischemia-Reperfusion Injury in Rat Ovaries Torsion and Detorsion Model. BULLETIN OF EMERGENCY AND TRAUMA BEAT[Internet]. 2018;6(3):207-216. Available from: https://sid.ir/paper/335129/en

    IEEE: Copy

    ALIREZA NAJAFPOUR, and Houman Azizizadeh, “Interaperitoneal Administration of Α lpha-Tocopherol Loaded Nanoparticles Improves Ischemia-Reperfusion Injury in Rat Ovaries Torsion and Detorsion Model,” BULLETIN OF EMERGENCY AND TRAUMA BEAT, vol. 6, no. 3, pp. 207–216, 2018, [Online]. Available: https://sid.ir/paper/335129/en

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