LYSOZYME FIBRILLATION INHIBITION BY PHLORIDZIN SMALL MOLECULES

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NEDAEI HADI; SABOURY ALI AKBAR; MERATAN ALI AKBAR; FALAHATI MOJTABA

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Journal Paper

Paper Information

Journal: MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS Year:2014 | Volume:3 | Issue:SUPPL. (1) Page(s): 232-232

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Information Journal Paper

Title

LYSOZYME FIBRILLATION INHIBITION BY PHLORIDZIN SMALL MOLECULES

Author(s)

NEDAEI HADI | SABOURY ALI AKBAR | MERATAN ALI AKBAR | FALAHATI MOJTABA

Keywords

HEN EGG WHITE LYSOZYME

AMYLOID

FIBRIL

Abstract

Amyloidogenic proteins undergo an alternative folding pathway under stressful conditions leading to formation of fibril products, presenting cross β-sheet structure which is the hallmark of many neurodegenerative diseases. The current work demonstrates the effectiveness of phloridzin small molecule on the inhibition of hen egg white lysozyme (HEWL) amyloid formation. The inhibitory effects were analyzed by thioflavin T-induced fluorescence, circular dichroism, and atomic force microscopy. This report demonstrated that naturally occurring small molecules may serve a function that is typically done by protein chaperones, and it provides a hint for designing inhibitors against amyloid formation products associated with neurodegenerative diseases. This report showed that phloridzin considerably hindered nucleation, and therefore, fibrillation of lysozyme in a dose-dependent manner.

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APA: Copy

NEDAEI, HADI, SABOURY, ALI AKBAR, MERATAN, ALI AKBAR, & FALAHATI, MOJTABA. (2014). LYSOZYME FIBRILLATION INHIBITION BY PHLORIDZIN SMALL MOLECULES. MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS, 3(SUPPL. (1)), 232-232. SID. https://sid.ir/paper/336023/en

Vancouver: Copy

NEDAEI HADI, SABOURY ALI AKBAR, MERATAN ALI AKBAR, FALAHATI MOJTABA. LYSOZYME FIBRILLATION INHIBITION BY PHLORIDZIN SMALL MOLECULES. MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS[Internet]. 2014;3(SUPPL. (1)):232-232. Available from: https://sid.ir/paper/336023/en

IEEE: Copy

HADI NEDAEI, ALI AKBAR SABOURY, ALI AKBAR MERATAN, and MOJTABA FALAHATI, “LYSOZYME FIBRILLATION INHIBITION BY PHLORIDZIN SMALL MOLECULES,” MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS, vol. 3, no. SUPPL. (1), pp. 232–232, 2014, [Online]. Available: https://sid.ir/paper/336023/en

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