ALBUMIN NANOPARTICLES CONTAINING COPPER COMPLEX AS SOD MIMETIC ENZYME

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DASHTESTANI FARIBA; GHOURCHIAN HEDAYATOLLAH; AZIZI MARZIEH

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Paper Information

Journal: MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS Year:2014 | Volume:3 | Issue:SUPPL. (1) Page(s): 120-120

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Information Journal Paper

Title

ALBUMIN NANOPARTICLES CONTAINING COPPER COMPLEX AS SOD MIMETIC ENZYME

Author(s)

DASHTESTANI FARIBA | GHOURCHIAN HEDAYATOLLAH | AZIZI MARZIEH

Keywords

NANO-ALBUMIN

COPPER

SOD MIMIC ENZYME

SUPEROXIDE RADICAL ANION

Abstract

Superoxide dismutase (SOD) is an antioxidant enzyme involved in scavenging of superoxide radical anion (O2-) and protects cells from oxidative damage. In cancer cells O2- production and low SOD activity may cause the malignant cells highly dependent on SOD for survival. In this research, albumin nanoparticles containing copper-cysteine complex (ANPs-CuCys) have been designed and evaluated as SOD mimetic enzyme. The inhibition of pyrogallol autoxidation assay (IC50 value) method was used for assaying SOD mimetic activity. Dynamic light scattering (DLS) was used for investigating surface properties of the ANPs-CuCys. The IC50 value (0.5 mg/ml) showed that ANPs-CuCys is a good O2- scavenger. The DLS results showed that the average diameter for diluted ANPs-CuCys was 28 nm. Zeta potential of ANPs-CuCys was -92 mV in pH 6.46. ANPs-CuCys is capable of removing the biologically important O2- and it may also be useful for medical treatment of oxidative stress diseases.

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APA: Copy

DASHTESTANI, FARIBA, GHOURCHIAN, HEDAYATOLLAH, & AZIZI, MARZIEH. (2014). ALBUMIN NANOPARTICLES CONTAINING COPPER COMPLEX AS SOD MIMETIC ENZYME. MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS, 3(SUPPL. (1)), 120-120. SID. https://sid.ir/paper/336143/en

Vancouver: Copy

DASHTESTANI FARIBA, GHOURCHIAN HEDAYATOLLAH, AZIZI MARZIEH. ALBUMIN NANOPARTICLES CONTAINING COPPER COMPLEX AS SOD MIMETIC ENZYME. MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS[Internet]. 2014;3(SUPPL. (1)):120-120. Available from: https://sid.ir/paper/336143/en

IEEE: Copy

FARIBA DASHTESTANI, HEDAYATOLLAH GHOURCHIAN, and MARZIEH AZIZI, “ALBUMIN NANOPARTICLES CONTAINING COPPER COMPLEX AS SOD MIMETIC ENZYME,” MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS, vol. 3, no. SUPPL. (1), pp. 120–120, 2014, [Online]. Available: https://sid.ir/paper/336143/en

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