Novel Isatin-based activator of p53 transcriptional functions in tumor cells

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Mirgayazova Regina; Khadiullina Raniya; Mingaleeva Rimma; Chasov Vitaly; Gomzikova Marina; Garanina Ekaterina; Rizvanov Albert; Bulatov Emil

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Journal: MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS Year:2019 | Volume:8 | Issue:3 Page(s): 119-128

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Title

Novel Isatin-based activator of p53 transcriptional functions in tumor cells

Author(s)

Keywords

p53

Transcriptional activity

Isatin-Schiff base

Metal complex

Tumor cells

Abstract

Bioinorganic medicinal chemistry remains a hot field for research aimed at developing novel anti-cancer treatments. Discovery of metal complexes as potent antitumor chemotherapeutics such as cisplatin led to a significant shift of focus toward organometallic/ bioinorganic compounds containing transition metals and their chelates as novel scaffolds for drug discovery. In that way, transition metal complexes coordinated to essential biological scaffolds represent a highly promising class of compounds for design of novel target-specific therapeutics. Here, we report novel data on p53 activating Isatin-based Cu(II) complex exhibiting cytotoxic properties towards HCT116 and MCF7 tumor cell lines, as confirmed by cell viability assay and flow cytometry analysis of apoptosis. Furthermore, putative p53-mediated mechanism of action of this compound is supported by quantitative analysis of TP53, MDM2 and PUMA genes expression, as well as luciferase-based p53 pathway activation assay. Multiplex immunoassay analysis of inflammatory markers revealed potential modulation of several cytokines and chemokines.

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APA: Copy

Mirgayazova, Regina, Khadiullina, Raniya, Mingaleeva, Rimma, Chasov, Vitaly, Gomzikova, Marina, Garanina, Ekaterina, Rizvanov, Albert, & Bulatov, Emil. (2019). Novel Isatin-based activator of p53 transcriptional functions in tumor cells. MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS, 8(3), 119-128. SID. https://sid.ir/paper/336289/en

Vancouver: Copy

Mirgayazova Regina, Khadiullina Raniya, Mingaleeva Rimma, Chasov Vitaly, Gomzikova Marina, Garanina Ekaterina, Rizvanov Albert, Bulatov Emil. Novel Isatin-based activator of p53 transcriptional functions in tumor cells. MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS[Internet]. 2019;8(3):119-128. Available from: https://sid.ir/paper/336289/en

IEEE: Copy

Regina Mirgayazova, Raniya Khadiullina, Rimma Mingaleeva, Vitaly Chasov, Marina Gomzikova, Ekaterina Garanina, Albert Rizvanov, and Emil Bulatov, “Novel Isatin-based activator of p53 transcriptional functions in tumor cells,” MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS, vol. 8, no. 3, pp. 119–128, 2019, [Online]. Available: https://sid.ir/paper/336289/en

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