CARDIOVASCULAR EFFECTS OF ACUTE ORGANOPHOSPHATE POISONING

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LAUDARI SHANKAR; PATOWARY BHANUMATI SAIKIA; SHARMA SANJIB KUMAR; DHUNGEL SACHIN; SUBEDI KUMUDINI; BHATTACHARYA RABINDRA; GURU PRASAD SONU; GANGAPATNAM SUBRAMANYAM

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Journal: Asia Pacific Journal of Medical Toxicology Year:2014 | Volume:3 | Issue:2 Page(s): 64-67

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Title

CARDIOVASCULAR EFFECTS OF ACUTE ORGANOPHOSPHATE POISONING

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Keywords

CARDIOVASCULAR ABNORMALITIES

ELECTROCARDIOGRAPHY

LONG QT SYNDROME

ORGANOPHOSPHATE POISONING

Abstract

Background: Cardiovascular effects of acute organophosphate (OP) poisoning are common. This study was aimed to assess the cardiovascular effects of OP poisoned patients in Nepal.Methods: This was a prospective hospital-based cross-sectional study of 115 acute OP poisoned patients presenting in emergency department of a tertiary care teaching hospital of central Nepal during November 2008 to October 2011. Cardiovascular manifestations were assessed by physical examination and electrocardiogram (ECG). All data including demographic features, clinical findings and outcomes were entered into a pre-structured proforma.Results: A total of 115 OP poisoned patients were studied. Mean age of the patients was 29.8±13.9 years. Fifty-seven patients (49.6%) developed cardiac effects that all had sinus tachycardia. Sinus bradycardia was observed in 3 patients (2.61%). Hypertension was detected in 23 patients (20%) and pulmonary edema developed in 24 patients (20.9%). The most common ECG abnormalities recorded were prolonged QTc in 21 patients (18.26%) and ventricular extra systole in 14 patients (12.2%). Five patients developed polymorphic ventricular tachycardia (VT) and 3 patients developed ventricular fibrillation (VF) which could not be reverted back despite adequate treatments and led to death (mortality rate: 6.9%).Conclusion: Cardiac effects of OP poisoning can be life-threatening. Prompt diagnosis, early supportive and definitive therapies with atropine and oximes along with vigilant monitoring of the patients for prominent cardiac effects such as QT prolongation, VT or VF during hospital stay can definitely save lives of the victims.

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APA: Copy

LAUDARI, SHANKAR, PATOWARY, BHANUMATI SAIKIA, SHARMA, SANJIB KUMAR, DHUNGEL, SACHIN, SUBEDI, KUMUDINI, BHATTACHARYA, RABINDRA, GURU PRASAD, SONU, & GANGAPATNAM, SUBRAMANYAM. (2014). CARDIOVASCULAR EFFECTS OF ACUTE ORGANOPHOSPHATE POISONING. ASIA PACIFIC JOURNAL OF MEDICAL TOXICOLOGY (APJMT), 3(2), 64-67. SID. https://sid.ir/paper/336382/en

Vancouver: Copy

LAUDARI SHANKAR, PATOWARY BHANUMATI SAIKIA, SHARMA SANJIB KUMAR, DHUNGEL SACHIN, SUBEDI KUMUDINI, BHATTACHARYA RABINDRA, GURU PRASAD SONU, GANGAPATNAM SUBRAMANYAM. CARDIOVASCULAR EFFECTS OF ACUTE ORGANOPHOSPHATE POISONING. ASIA PACIFIC JOURNAL OF MEDICAL TOXICOLOGY (APJMT)[Internet]. 2014;3(2):64-67. Available from: https://sid.ir/paper/336382/en

IEEE: Copy

SHANKAR LAUDARI, BHANUMATI SAIKIA PATOWARY, SANJIB KUMAR SHARMA, SACHIN DHUNGEL, KUMUDINI SUBEDI, RABINDRA BHATTACHARYA, SONU GURU PRASAD, and SUBRAMANYAM GANGAPATNAM, “CARDIOVASCULAR EFFECTS OF ACUTE ORGANOPHOSPHATE POISONING,” ASIA PACIFIC JOURNAL OF MEDICAL TOXICOLOGY (APJMT), vol. 3, no. 2, pp. 64–67, 2014, [Online]. Available: https://sid.ir/paper/336382/en

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