مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Superiority of Buprenorphine over Suboxone in Preventing Addiction Relapse in Opioid Addicts under Maintenance Therapy: A Double-Blind Clinical Trial

Pages

  1-6

Abstract

 Background: In maintenance therapy for opioid addiction, to reduce the risk of Buprenorphine (BUP) abuse, the combination of BUP and naloxone (NX) has been developed and is commercially available as suboxone (BUP/NX). This study was designed to compare addiction relapse frequency in patients receiving BUP and BUP/NX as maintenance therapy. Methods: In this double-blind clinical trial with cross over design, 100 opioid abusers were randomly assigned to two treatment groups to receive either BUP or BUP/NX. After three months, without a time-out period, subjects undertook treatment with the other drug. The subjects were screened weekly for urinary morphine. Results: In each of the study arms, when the patients were given BUP/NX, the number of relapses was significantly higher compared to when they received BUP (0. 13± 0. 24 vs. 0. 04± 0. 09, P = 0. 001). If participants’ age was taken into account, the number of relapses was significantly higher when BUP/NX was given in age groups of 31 to 40 years and over 50 years (P < 0. 05). The length of addiction had also a significant impact on the number of relapses, i. e., patients with over 10-year history of addiction had higher number of relapses if they were given BUP/NX compared with BUP (P < 0. 05). Conclusion: BUP seems to be more effective than BUP/NX in preventing addiction relapse in opioid abusers under maintenance treatment.

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    Cite

    APA: Copy

    SHOJAEI GHALEHNEY, ZAHRA, ILBEIGI, SHAHRAM, ARSHADI, HAMID REZA, & AFSHARI, REZA. (2018). Superiority of Buprenorphine over Suboxone in Preventing Addiction Relapse in Opioid Addicts under Maintenance Therapy: A Double-Blind Clinical Trial. ASIA PACIFIC JOURNAL OF MEDICAL TOXICOLOGY (APJMT), 7(1), 1-6. SID. https://sid.ir/paper/336412/en

    Vancouver: Copy

    SHOJAEI GHALEHNEY ZAHRA, ILBEIGI SHAHRAM, ARSHADI HAMID REZA, AFSHARI REZA. Superiority of Buprenorphine over Suboxone in Preventing Addiction Relapse in Opioid Addicts under Maintenance Therapy: A Double-Blind Clinical Trial. ASIA PACIFIC JOURNAL OF MEDICAL TOXICOLOGY (APJMT)[Internet]. 2018;7(1):1-6. Available from: https://sid.ir/paper/336412/en

    IEEE: Copy

    ZAHRA SHOJAEI GHALEHNEY, SHAHRAM ILBEIGI, HAMID REZA ARSHADI, and REZA AFSHARI, “Superiority of Buprenorphine over Suboxone in Preventing Addiction Relapse in Opioid Addicts under Maintenance Therapy: A Double-Blind Clinical Trial,” ASIA PACIFIC JOURNAL OF MEDICAL TOXICOLOGY (APJMT), vol. 7, no. 1, pp. 1–6, 2018, [Online]. Available: https://sid.ir/paper/336412/en

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