COMPARISON OF THE EFFECT OF CLOMIPHENE CITRATE AND THE LETROZOLE FOR OVULATION INDUCTION IN INFERTILE WOMEN WITH POLYCYSTIC OVARIAN SYNDROME

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

RAHMANI E.; AHMADI SH.; MOTAMED N.; MANESHI H.; GHASEMI S.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: IRANIAN SOUTH MEDICAL JOURNAL (ISMJ) Year:2012 | Volume:15 | Issue:3 Page(s): 193-200

Download Full-Text

Persian Verion

View:

61,386

Download:

Cites:

Information Journal Paper

Title

COMPARISON OF THE EFFECT OF CLOMIPHENE CITRATE AND THE LETROZOLE FOR OVULATION INDUCTION IN INFERTILE WOMEN WITH POLYCYSTIC OVARIAN SYNDROME

Author(s)

Keywords

CLOMIPHENEQ2

LETROZOLEQ2

POLYCYSTIC OVARIAN SYNDROMEQ2

INFERTILITYQ2

Abstract

Background: Anovulation is one of the most common causes of INFERTILITY. Different drugs in variousroutes are prescribed for its treatment. CLOMIPHENE citrate (CLOMIPHENE) and LETROZOLE are categorized as ovulation induction drugs. In the present study, the effect of CLOMIPHENE and LETROZOLE, using step up method, is compared with each other in the treatment of INFERTILITY.Materials and Methods: In a randomized controlled clinical trial, 200 infertile patients with anovulation referred to INFERTILITY clinic of Bushehr University of Medical Sciences during 2008-2010 were studied in two equal groups. Informed written consent was obtained from all patients. For patients in each group, LETROZOLE or CLOMIPHENE was prescribed from the third day of menstruation for five days in an increasing protocol of one, two and three tablets. Ovulation and endometrial thickness were evaluated by ultrasonography in 13th-14th days and pregnancy was confirmed by bHCG.Results: There were nosignificant differences regarding baseline demographic and fertility variables between two groups (p value>0.05). Follicle formation (P value=0.9), pregnancy rate (CLOMIPHENE 14.54% and LETROZOLE 12.26%, P value=0.19), abortion rate and drug side effects were similar between two groups (p value> 0.05). In LETROZOLE group, endometrial thickness was significantly lesser than CLOMIPHENE group. Estradiol level per follicle was higher in LETROZOLE group (108.3+17.44) in comparison with CLOMIPHENE group (172.4+20.33) (P value<0.0001).Conclusion: It seems that CLOMIPHENE and LETROZOLE effectiveness in treating INFERTILITY due to anovulation are the same. Moreover, they are similar in ovulation induction and pregnancy rate. Considering patient compliance, cost and drug side effects one.

Cites

References

No record.

Cite

APA: Copy

RAHMANI, E., AHMADI, SH., MOTAMED, N., MANESHI, H., & GHASEMI, S.. (2012). COMPARISON OF THE EFFECT OF CLOMIPHENE CITRATE AND THE LETROZOLE FOR OVULATION INDUCTION IN INFERTILE WOMEN WITH POLYCYSTIC OVARIAN SYNDROME. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), 15(3), 193-200. SID. https://sid.ir/paper/33647/en

Vancouver: Copy

RAHMANI E., AHMADI SH., MOTAMED N., MANESHI H., GHASEMI S.. COMPARISON OF THE EFFECT OF CLOMIPHENE CITRATE AND THE LETROZOLE FOR OVULATION INDUCTION IN INFERTILE WOMEN WITH POLYCYSTIC OVARIAN SYNDROME. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ)[Internet]. 2012;15(3):193-200. Available from: https://sid.ir/paper/33647/en

IEEE: Copy

E. RAHMANI, SH. AHMADI, N. MOTAMED, H. MANESHI, and S. GHASEMI, “COMPARISON OF THE EFFECT OF CLOMIPHENE CITRATE AND THE LETROZOLE FOR OVULATION INDUCTION IN INFERTILE WOMEN WITH POLYCYSTIC OVARIAN SYNDROME,” IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), vol. 15, no. 3, pp. 193–200, 2012, [Online]. Available: https://sid.ir/paper/33647/en

Related Journal Papers