THE EFFECT OF CRUDE EXTRACT OF TURBO CORONATUS FROM THE PERSIAN GULF ON SERUM BIOCHEMICAL PARAMETERS AND HEMATIOLOGICAL PARAMETERS OF RATS

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VAZIRIZADEH A.; MOHEBBI GH.; NABIPOUR I.

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Journal: IRANIAN SOUTH MEDICAL JOURNAL (ISMJ) Year:2017 | Volume:20 | Issue:2 Page(s): 207-216

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Title

THE EFFECT OF CRUDE EXTRACT OF TURBO CORONATUS FROM THE PERSIAN GULF ON SERUM BIOCHEMICAL PARAMETERS AND HEMATIOLOGICAL PARAMETERS OF RATS

Author(s)

VAZIRIZADEH A. | MOHEBBI GH. | NABIPOUR I. | Issue Writer Certificate

Keywords

TURBO CORONATUSQ1

HEMOLYSISQ3

RHABDOMYOLYSISQ1

HEPATOTOXICITYQ2

PERSIAN GULFQ2

Abstract

Background: Turbotoxins are marine secondary metabolites that produce in Turbinidae family and were isolated from Japanese Turbo marmorata for the first time. A few research has been done on these metabolites so far. Another species, TURBO CORONATUS exists in Iran. The main aim of the current project was to investigate some biological effects of the crude extract of TURBO CORONATUS from the PERSIAN GULF Materials and methods: In this study, 18 rats were selected in three groups including the control group. The experimental groups received 1/2 and 1/3 lethal doses intravenously and serum levels of liver and muscle enzymes, electrolytes and complete blood counts (CBC) were measured after 24 hours.Results: The levels of liver and muscle enzymes, amylase, sodium, potassium, calcium, phosphorus, ferrous, haptoglobin, albumin and creatinine were significantly increased in experimental group compared with the control group by injection of crude extract of TURBO CORONATUS; however, hemoglobin, mean corpuscular volume (MCV), red blood cell count, magnesium, and glucose levels were significantly decreased in the experimental group compared with the control group.Conclusions: Intravenous injection of 1/2 and 1/3 lethal doses of the crude extract of TURBO CORONATUS to rats produced RHABDOMYOLYSIS and hepatocytes injury. In addition, the crude extract injection acted as a haematoxin and decreased hemoglobin and MCV.

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APA: Copy

VAZIRIZADEH, A., MOHEBBI, GH., & NABIPOUR, I.. (2017). THE EFFECT OF CRUDE EXTRACT OF TURBO CORONATUS FROM THE PERSIAN GULF ON SERUM BIOCHEMICAL PARAMETERS AND HEMATIOLOGICAL PARAMETERS OF RATS. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), 20(2), 207-216. SID. https://sid.ir/paper/33676/en

Vancouver: Copy

VAZIRIZADEH A., MOHEBBI GH., NABIPOUR I.. THE EFFECT OF CRUDE EXTRACT OF TURBO CORONATUS FROM THE PERSIAN GULF ON SERUM BIOCHEMICAL PARAMETERS AND HEMATIOLOGICAL PARAMETERS OF RATS. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ)[Internet]. 2017;20(2):207-216. Available from: https://sid.ir/paper/33676/en

IEEE: Copy

A. VAZIRIZADEH, GH. MOHEBBI, and I. NABIPOUR, “THE EFFECT OF CRUDE EXTRACT OF TURBO CORONATUS FROM THE PERSIAN GULF ON SERUM BIOCHEMICAL PARAMETERS AND HEMATIOLOGICAL PARAMETERS OF RATS,” IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), vol. 20, no. 2, pp. 207–216, 2017, [Online]. Available: https://sid.ir/paper/33676/en

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