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Information Journal Paper

Title

EVALUATION OF ANTI-MALARIAL ACTIVITY OF ARTEMISIA TURCOMANICA AND A. KOPETDAGHENSIS BY CELL-FREE β-HEMATIN FORMATION ASSAY

Pages

  59-65

Abstract

 Background and objectives: The plants of genus Artemisia (Asteraceae) have been conventionally used for prevention and medication of a number of ailments. In the present research, ten extracts with different polarities from aerial parts of two Artemisia species, A. kopetdaghensis and A. turcomanica were evaluated for their potential ANTI-MALARIAl properties.Methods: The plant materials were extracted successively with petroleum ether (PE), dichloromethane (DCM), ethyl acetate (EtOAC), ethanol, and ethanol-water (1: 1 v/v) by cold maceration method. Cell free b -hematin formation assay were used for assessing ANTI-MALARIAl activity of obtained extracts.Results: DCM extract of A. kopetdaghensis and PE extract of A. turcomanica showed remarkable ANTI-MALARIAl activity with IC50 values of 1.04±0.02 mg/mL and 0.90±0.27 mg/mL, respectively, compared to positive control (chloroquine, IC50 0.04±0.01 mg/mL).Conclusion: It seems that the ANTI-MALARIAl activity of these extracts might be bound up with the presence of compounds with low or medium polarity; hence, this preliminary test indicated that these potent extracts could be considered for further investigations to find new sources of ANTI-MALARIAl phytochemicals.

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  • Cite

    APA: Copy

    MOJARRAB, M., EMAMI, S.A., GHEIBI, SH., TALEB, A.M., & HESHMATI AFSHAR, F.. (2016). EVALUATION OF ANTI-MALARIAL ACTIVITY OF ARTEMISIA TURCOMANICA AND A. KOPETDAGHENSIS BY CELL-FREE β-HEMATIN FORMATION ASSAY. RESEARCH JOURNAL OF PHARMACOGNOSY, 3(4), 59-65. SID. https://sid.ir/paper/336795/en

    Vancouver: Copy

    MOJARRAB M., EMAMI S.A., GHEIBI SH., TALEB A.M., HESHMATI AFSHAR F.. EVALUATION OF ANTI-MALARIAL ACTIVITY OF ARTEMISIA TURCOMANICA AND A. KOPETDAGHENSIS BY CELL-FREE β-HEMATIN FORMATION ASSAY. RESEARCH JOURNAL OF PHARMACOGNOSY[Internet]. 2016;3(4):59-65. Available from: https://sid.ir/paper/336795/en

    IEEE: Copy

    M. MOJARRAB, S.A. EMAMI, SH. GHEIBI, A.M. TALEB, and F. HESHMATI AFSHAR, “EVALUATION OF ANTI-MALARIAL ACTIVITY OF ARTEMISIA TURCOMANICA AND A. KOPETDAGHENSIS BY CELL-FREE β-HEMATIN FORMATION ASSAY,” RESEARCH JOURNAL OF PHARMACOGNOSY, vol. 3, no. 4, pp. 59–65, 2016, [Online]. Available: https://sid.ir/paper/336795/en

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