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Information Journal Paper

Title

Antidepressant Effect of Asperugo procumbens L. in Comparison with Fluoxetine: a Randomized Double Blind Clinical Trial

Pages

  15-20

Abstract

 Background and objectives: Aseprugo procumbens is used as antianxety and depression in Iranian traditional medicine; however no clinical trial has been performed about these properties. The aim of this study was to evaluate the antidepressant efficacy and safety of hydroalcoholic extract of A. procumbens. Methods: In this double blind study, 30 outpatients with mild to moderate depressive disorder (according to DMS-IV-TR criteria who had a score of 18-25 on the Hamilton depression Rating Scale (HDRS) were randomly divided in two group, 1) received 10 mg fluoxetine capsule, 2) received 1. 2 g dried extract of A. procumbens capsule (6 mg flavonoid, ) orally per day. Patients were followed up for 6 weeks; the recovery process was assessed by the HDRS in weeks 0, 2, 4 and 6. Results: A significant decrease in HDRS was observed in both groups after the fourth week. After the sixth week, fluoxetine had a greater anti-depressant activity than A. procumbens (p value =0. 03). There were no significant differences in terms of adverse effects in both groups. Conclusions: The hydroalcoholic extract of A. procumbens can be considered as an effective and safe remedy for mild to moderate depressive disorder.

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    APA: Copy

    ZARGHAMI, MEHRAN, CHABRA, AROONA, AZADBAKHT, MOHAMMAD, KHALILIAN, ALIREZA, & HOSSEINI, ALI ASGHAR. (2018). Antidepressant Effect of Asperugo procumbens L. in Comparison with Fluoxetine: a Randomized Double Blind Clinical Trial. RESEARCH JOURNAL OF PHARMACOGNOSY, 5(3), 15-20. SID. https://sid.ir/paper/336827/en

    Vancouver: Copy

    ZARGHAMI MEHRAN, CHABRA AROONA, AZADBAKHT MOHAMMAD, KHALILIAN ALIREZA, HOSSEINI ALI ASGHAR. Antidepressant Effect of Asperugo procumbens L. in Comparison with Fluoxetine: a Randomized Double Blind Clinical Trial. RESEARCH JOURNAL OF PHARMACOGNOSY[Internet]. 2018;5(3):15-20. Available from: https://sid.ir/paper/336827/en

    IEEE: Copy

    MEHRAN ZARGHAMI, AROONA CHABRA, MOHAMMAD AZADBAKHT, ALIREZA KHALILIAN, and ALI ASGHAR HOSSEINI, “Antidepressant Effect of Asperugo procumbens L. in Comparison with Fluoxetine: a Randomized Double Blind Clinical Trial,” RESEARCH JOURNAL OF PHARMACOGNOSY, vol. 5, no. 3, pp. 15–20, 2018, [Online]. Available: https://sid.ir/paper/336827/en

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