The Effects of Different Dose of Chronic Ritalin on the Brain of Prepubertal Female Balb/C Mice

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KATEBI AMIR REZA; GOLAB FERESHTEH; VAHABZADEH GELAREH; SARVEAZAD ARASH; Goodarzi Nasim; FAZELIPOUR SIMIN; Brati Mahmood; SOLEIMANI MANSOUREH

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Journal: Journal of Pediatric Perspectives Year:2018 | Volume:6 | Issue:7 (55) Page(s): 7883-7892

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Title

The Effects of Different Dose of Chronic Ritalin on the Brain of Prepubertal Female Balb/C Mice

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Keywords

Apoptosis

Brain

Mice

Methylphenidate

Ritalin

Abstract

Background Methylphenidate (MPH) is commonly prescribed for children who have been diagnosed with attention deficit hyperactivity disorder (ADHD); however, the action mechanisms of Methylphenidate have not been fully elucidated. Studies have shown a relationship between Apoptosis signaling pathways and psychiatric disorders, as well as therapeutic targets for such disorders. So, we examined the effects of chronic Methylphenidate administration on the Brain of Mice. Materials and Methods Animals were administered MPH at doses of 2, 5 and 10 mg/kg for 60 days. At the age of three months and in estrous phase, brian tissues were removed and washed in cold phosphate-buffered saline and some of them were frozen at-80oC for Western blot analysis. We measured the levels of pro-apoptotic protein, Bax and anti-apoptoticprotein, Bcl-2, in the Brain of neonate female Balb/c Mice. The rest of the Brains were fixed in formalin (10% phosphate-buffered, pH = 7. 4). Then samples were embedded in paraffin according to routine histologic procedures. Results: Our results showed that MPH with a dose of 10 mg/kg causes a considerable increase in the level of the Bax protein as compared with other groups. In contrast, in the partial cortex of female Mice under treatment with high dose of MPH (10 mg/kg) could less Bcl2 levels as compared with 5 mg/kg MPH. However, 5 mg/kg MPH have a significant effect on Bcl2 levels compare with each of mentioned doses (P<0. 05). Conclusion Our results suggest that long-term administration of MPH in the mouse Brain had influence on the cascade of Apoptosis and its effects, depends on dose rate.

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APA: Copy

KATEBI, AMIR REZA, GOLAB, FERESHTEH, VAHABZADEH, GELAREH, SARVEAZAD, ARASH, Goodarzi, Nasim, FAZELIPOUR, SIMIN, Brati, Mahmood, & SOLEIMANI, MANSOUREH. (2018). The Effects of Different Dose of Chronic Ritalin on the Brain of Prepubertal Female Balb/C Mice. INTERNATIONAL JOURNAL OF PEDIATRICS, 6(7 (55)), 7883-7892. SID. https://sid.ir/paper/337552/en

Vancouver: Copy

KATEBI AMIR REZA, GOLAB FERESHTEH, VAHABZADEH GELAREH, SARVEAZAD ARASH, Goodarzi Nasim, FAZELIPOUR SIMIN, Brati Mahmood, SOLEIMANI MANSOUREH. The Effects of Different Dose of Chronic Ritalin on the Brain of Prepubertal Female Balb/C Mice. INTERNATIONAL JOURNAL OF PEDIATRICS[Internet]. 2018;6(7 (55)):7883-7892. Available from: https://sid.ir/paper/337552/en

IEEE: Copy

AMIR REZA KATEBI, FERESHTEH GOLAB, GELAREH VAHABZADEH, ARASH SARVEAZAD, Nasim Goodarzi, SIMIN FAZELIPOUR, Mahmood Brati, and MANSOUREH SOLEIMANI, “The Effects of Different Dose of Chronic Ritalin on the Brain of Prepubertal Female Balb/C Mice,” INTERNATIONAL JOURNAL OF PEDIATRICS, vol. 6, no. 7 (55), pp. 7883–7892, 2018, [Online]. Available: https://sid.ir/paper/337552/en

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