Methicillin-Resistant Staphylococcus Aureus in Melanesian Children with Haematogenous Osteomyelitis from the Central Highlands of Papua New Guinea

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Aglua Izzard; Jaworski Jan; Drekore Jimmy; Urakoko Bohu; Poka Harry; Michael Audrey; Greenhill Andrew

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Journal: Journal of Pediatric Perspectives Year:2018 | Volume:6 | Issue:10 (58) Page(s): 8361-8370

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Title

Methicillin-Resistant Staphylococcus Aureus in Melanesian Children with Haematogenous Osteomyelitis from the Central Highlands of Papua New Guinea

Author(s)

Keywords

Children

MRSA

Osteomyelitis

Papua New Guinea

Abstract

Background: Methicillin-Resistant Staphylococcus aureus (MRSA) has been an important cause of bone infection since the 1940s. Current guidelines recommend targeted antibiotic use for Osteomyelitis treatment informed by microbial sensitivity patterns. However, in settings without microbiology facilities, empirical antibiotic use is common. Unrecognized antibiotic resistance potentiates persistence of MRSA with Osteomyelitis progression to chronic forms with complications despite antibiotic treatment. Materials and Methods: A prospective observational study was done to identify common etiological agent (s) in bone infection in Melanesian Children (that were admitted to the two surgical and one pediatric wards of the SJNM-KUGH in the Simbu province of Papua New Guinea in 2012 and 2017), observe for presence of antimicrobial resistance, and determine effective antibiotic regimes for treatment of bone pediatric Osteomyelitis. Seventy pediatric patients presenting from the community with Osteomyelitis were recruited, with bone and non-bone specimens sampled, cultured and isolates tested for resistance to common antibiotics. Results: Staphylococcus aureus (S. aureus) was isolated in 67% (47/70) of collected specimens. Of the 47 isolates, there was 91. 5% resistance to penicillin, 85. 1% resistance to methicillin, 89. 4% resistance to oxacillin, 93. 6% resistance to ampicillin and 80. 9% resistance to ceftriaxone. S. aureus showed 91. 5% sensitivity to gentamycin, 93. 6% sensitivity to erythromycin, tetracycline and clindamycin, and 95. 7% sensitivity to Co-trimoxazole. Conclusion: MRSA was the leading cause of haematogenous Osteomyelitis in Melanesian Children. S. aureus was isolated mainly from infected long bones of the lower limbs (79%) of Children presenting from the community, suggesting a predominantly community-associated MRSA.

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APA: Copy

Aglua, Izzard, Jaworski, Jan, Drekore, Jimmy, Urakoko, Bohu, Poka, Harry, Michael, Audrey, & Greenhill, Andrew. (2018). Methicillin-Resistant Staphylococcus Aureus in Melanesian Children with Haematogenous Osteomyelitis from the Central Highlands of Papua New Guinea. INTERNATIONAL JOURNAL OF PEDIATRICS, 6(10 (58)), 8361-8370. SID. https://sid.ir/paper/337608/en

Vancouver: Copy

Aglua Izzard, Jaworski Jan, Drekore Jimmy, Urakoko Bohu, Poka Harry, Michael Audrey, Greenhill Andrew. Methicillin-Resistant Staphylococcus Aureus in Melanesian Children with Haematogenous Osteomyelitis from the Central Highlands of Papua New Guinea. INTERNATIONAL JOURNAL OF PEDIATRICS[Internet]. 2018;6(10 (58)):8361-8370. Available from: https://sid.ir/paper/337608/en

IEEE: Copy

Izzard Aglua, Jan Jaworski, Jimmy Drekore, Bohu Urakoko, Harry Poka, Audrey Michael, and Andrew Greenhill, “Methicillin-Resistant Staphylococcus Aureus in Melanesian Children with Haematogenous Osteomyelitis from the Central Highlands of Papua New Guinea,” INTERNATIONAL JOURNAL OF PEDIATRICS, vol. 6, no. 10 (58), pp. 8361–8370, 2018, [Online]. Available: https://sid.ir/paper/337608/en

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