Evaluation of Clarithromycin and Metronidazole Resistance of Helicobacter Pylori Infection in Symptomatic Iranian Children

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Haghighi Mohammad Bagher; DARA NAGHI; MANSOUR GHANAIE ROXANA; AZIMI LEILA; HOSSEINI AMIRHOSSEIN; TAJALLI SALEHEH; HAJIPOUR MAHMOUD; SAYYARI ALIAKBAR; IMANZADEH FARID; KHATAMI KATAYOUN; ROHANI PEJMAN; OLANG BEHESHTEH

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Journal: Journal of Pediatric Perspectives Year:2019 | Volume:7 | Issue:2 (62) Page(s): 8925-8933

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Title

Evaluation of Clarithromycin and Metronidazole Resistance of Helicobacter Pylori Infection in Symptomatic Iranian Children

Author(s)

Keywords

Antibiotic Resistance

Children

Helicobacter Pylori

Infection

Abstract

Background Helicobacter Pylori (H. pylori) as a gram-negative bacterium is the most common Infection of the gastrointestinal tract, and worldwide it affects the Children over three years of age. H. pylori could cause gastrointestinal and extra-intestinal manifestations. Antibiotic Resistance can happen primarily and occurs during treatment. We aimed to evaluate the resistance gene of H. pylori obtained from gastric biopsy by polymerase chain reaction (PCR) method in Iranian Children over 3 years old. Materials and Methods This study was a cross-sectional to evaluate the resistance gene of H. pylori obtained from gastric biopsy by polymerase chain reaction method for metronidazole and clarithromycin in Children over three years old referring to the Mofid Children's Medical Center in Tehran, Iran. Results: Finally, data from seventy-nine samples included (mean age=10. 7 years and male gender = 60. 8%). Beta Globulin (BG) gene were detectable in 75 (94. 93%) specimens of 79 (100%). Seventeen out of 75 specimens showed positive results for molecular detection of H. pylori. The results of RFLP-PCR technique showed that mutation of RdxA gene in seven of 17 (41. 1%) for Metronidazole resistance and one case of 17 (5. 8%) mutation of 23Y RNA gene that leads to clarithromycin resistance. Conclusion Regarding the results of our study, it is better to check microbial resistance by culture and antibiogram for the antibiotic regimen of the first and second line of H. pylori treatment in Children.

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References

The magnitude of antibiotic resistance to Helicobacter pylori in Africa and identified mutations which confer resistance to antibiotics: systematic review and meta-analysis

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APA: Copy

Haghighi, Mohammad Bagher, DARA, NAGHI, MANSOUR GHANAIE, ROXANA, AZIMI, LEILA, HOSSEINI, AMIRHOSSEIN, TAJALLI, SALEHEH, HAJIPOUR, MAHMOUD, SAYYARI, ALIAKBAR, IMANZADEH, FARID, KHATAMI, KATAYOUN, ROHANI, PEJMAN, & OLANG, BEHESHTEH. (2019). Evaluation of Clarithromycin and Metronidazole Resistance of Helicobacter Pylori Infection in Symptomatic Iranian Children. INTERNATIONAL JOURNAL OF PEDIATRICS, 7(2 (62)), 8925-8933. SID. https://sid.ir/paper/337628/en

Vancouver: Copy

Haghighi Mohammad Bagher, DARA NAGHI, MANSOUR GHANAIE ROXANA, AZIMI LEILA, HOSSEINI AMIRHOSSEIN, TAJALLI SALEHEH, HAJIPOUR MAHMOUD, SAYYARI ALIAKBAR, IMANZADEH FARID, KHATAMI KATAYOUN, ROHANI PEJMAN, OLANG BEHESHTEH. Evaluation of Clarithromycin and Metronidazole Resistance of Helicobacter Pylori Infection in Symptomatic Iranian Children. INTERNATIONAL JOURNAL OF PEDIATRICS[Internet]. 2019;7(2 (62)):8925-8933. Available from: https://sid.ir/paper/337628/en

IEEE: Copy

Mohammad Bagher Haghighi, NAGHI DARA, ROXANA MANSOUR GHANAIE, LEILA AZIMI, AMIRHOSSEIN HOSSEINI, SALEHEH TAJALLI, MAHMOUD HAJIPOUR, ALIAKBAR SAYYARI, FARID IMANZADEH, KATAYOUN KHATAMI, PEJMAN ROHANI, and BEHESHTEH OLANG, “Evaluation of Clarithromycin and Metronidazole Resistance of Helicobacter Pylori Infection in Symptomatic Iranian Children,” INTERNATIONAL JOURNAL OF PEDIATRICS, vol. 7, no. 2 (62), pp. 8925–8933, 2019, [Online]. Available: https://sid.ir/paper/337628/en

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