Ketamine Associated Vomiting in Children Requiring Sedation: A Prospective Randomized Open Trial Study

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MOTAMED HASSAN; MALEKI VERKI MOHAMMAD REZA; MOZAFARI JAVAD; FOROUZAN ARASH

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Journal Paper

Paper Information

Journal: Journal of Pediatric Perspectives Year:2018 | Volume:6 | Issue:12 (60) Page(s): 8611-8618

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Title

Ketamine Associated Vomiting in Children Requiring Sedation: A Prospective Randomized Open Trial Study

Author(s)

MOTAMED HASSAN | MALEKI VERKI MOHAMMAD REZA | MOZAFARI JAVAD | FOROUZAN ARASH | Issue Writer Certificate

Keywords

Emergency Department

Ketamine

Sedation

Vomiting

Abstract

Background In recent years, Ketamine has been the most used sedative in Emergency Department (ED) procedures for pain management. Therefore, this study evaluated Ketamine associated Vomiting (KAV) in children requiring Sedation. Materials and Methods This is a prospective, randomized, and open trial study carried out on children of ages 3 months to 13 years requiring Sedation for medical diagnostic or treatment procedures. The patients were randomized into 1 mg/kg IV, 2 mg/kg IV, 3 mg/kg IM and 5 mg/kg IM groups. Results A total of 190 patients were enrolled for this study. In total, 17. 37% of the children were reported to have vomited after Ketamine administration. In the IV group, 21. 69% of the children vomited, while in the IM group, 14. 02% vomited (p= 0. 18). In the 1 mg/kg IV group, 22. 72% of the children vomited compared to 20. 51% (p= 0. 51) in the 2 mg/kg IV group. In the 3 mg/kg IM group, 14. 54% of the children vomited as against 13. 46% in the 5 mg/kg IM group (p= 0. 54). There were no significant differences between sex and dose group on the incidence of Vomiting (p= 0. 40). Conclusion This study showed that the administration of Ketamine via IV and IM in a standard dose is a safe method for sedating children. However, there is need to study the combination of Ketamine with anti-Vomiting agents in different injection routes, as well as to review the combination with tranquilizer to minimize the rate of Vomiting in children requiring Sedation in the ED.

Cites

Comparison of the Efficacy and Side Effects of Intravenous and Intramuscular Injection of Ketamine for Children Requiring Sedation: A Randomized Double-Blind Clinical Trial Study

References

Demonstration of analgesic effect of intranasal ketamine and intranasal fentanyl for postoperative pain after pediatric tonsillectomy

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APA: Copy

MOTAMED, HASSAN, MALEKI VERKI, MOHAMMAD REZA, MOZAFARI, JAVAD, & FOROUZAN, ARASH. (2018). Ketamine Associated Vomiting in Children Requiring Sedation: A Prospective Randomized Open Trial Study. INTERNATIONAL JOURNAL OF PEDIATRICS, 6(12 (60)), 8611-8618. SID. https://sid.ir/paper/337703/en

Vancouver: Copy

MOTAMED HASSAN, MALEKI VERKI MOHAMMAD REZA, MOZAFARI JAVAD, FOROUZAN ARASH. Ketamine Associated Vomiting in Children Requiring Sedation: A Prospective Randomized Open Trial Study. INTERNATIONAL JOURNAL OF PEDIATRICS[Internet]. 2018;6(12 (60)):8611-8618. Available from: https://sid.ir/paper/337703/en

IEEE: Copy

HASSAN MOTAMED, MOHAMMAD REZA MALEKI VERKI, JAVAD MOZAFARI, and ARASH FOROUZAN, “Ketamine Associated Vomiting in Children Requiring Sedation: A Prospective Randomized Open Trial Study,” INTERNATIONAL JOURNAL OF PEDIATRICS, vol. 6, no. 12 (60), pp. 8611–8618, 2018, [Online]. Available: https://sid.ir/paper/337703/en

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