Use of Oral Sirolimus in Paediatric Patients with Serious Vascular Anomalies: Case Report

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Garcia Verde Maria Jesus; Roca Cristina Martinez; Gomez Pedro Yanez; Martin Herranz Maria Isabel

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Journal Paper

Paper Information

Journal: Journal of Pediatric Perspectives Year:2018 | Volume:6 | Issue:1 (49) Page(s): 6873-6877

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Information Journal Paper

Title

Use of Oral Sirolimus in Paediatric Patients with Serious Vascular Anomalies: Case Report

Author(s)

Garcia Verde Maria Jesus | Roca Cristina Martinez | Gomez Pedro Yanez | Martin Herranz Maria Isabel | Issue Writer Certificate

Keywords

Pediatric Patients

Sirolimus

Vascular Anomalies

Abstract

Background Pediatric Vascular Anomalies comprise a heterogeneous group of clinical disorders of varying severity. These anomalies are divided into vascular tumors or vascular malformations. Different therapeutic strategies have been used depending on the pathology in question. In recent years, mammalian target of rapamycin (mTOR) inhibitors have been explored as a therapeutic option in patients with complex Vascular Anomalies that fail to respond to conventional therapies. Case Report Two patients affected by complicated Vascular Anomalies were treated with Sirolimus. Case 1: fourteen-month-old male patient with primary congenital lymphedema in the right arm. Case 2: boy aged two years and eight months, diagnosed with a non-respectable cervical aposiform hemangioendothelioma (KHE). Both patients received Sirolimus at doses of 0. 8 mg/m2/12 h during 12 and 13 months respectively. Monitoring plasma Sirolimus concentrations made it possible to safely deal with problems associated with the medication. Both patients experiment an important improvement of their pathology, maintained after suspending treatment. No adverse effects related to treatment with Sirolimus were observed. Conclusion Oral Sirolimus proved to be an effective strategy in the treatment of complicated Vascular Anomalies in our pediatric population.

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APA: Copy

Garcia Verde, Maria Jesus, Roca, Cristina Martinez, Gomez, Pedro Yanez, & Martin Herranz, Maria Isabel. (2018). Use of Oral Sirolimus in Paediatric Patients with Serious Vascular Anomalies: Case Report. INTERNATIONAL JOURNAL OF PEDIATRICS, 6(1 (49)), 6873-6877. SID. https://sid.ir/paper/337723/en

Vancouver: Copy

Garcia Verde Maria Jesus, Roca Cristina Martinez, Gomez Pedro Yanez, Martin Herranz Maria Isabel. Use of Oral Sirolimus in Paediatric Patients with Serious Vascular Anomalies: Case Report. INTERNATIONAL JOURNAL OF PEDIATRICS[Internet]. 2018;6(1 (49)):6873-6877. Available from: https://sid.ir/paper/337723/en

IEEE: Copy

Maria Jesus Garcia Verde, Cristina Martinez Roca, Pedro Yanez Gomez, and Maria Isabel Martin Herranz, “Use of Oral Sirolimus in Paediatric Patients with Serious Vascular Anomalies: Case Report,” INTERNATIONAL JOURNAL OF PEDIATRICS, vol. 6, no. 1 (49), pp. 6873–6877, 2018, [Online]. Available: https://sid.ir/paper/337723/en

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