Diagnostic Value of NT-pro BNP Biomarker and Echocardiography in Cardiac Involvements in Beta-thalassemia Patients

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NOORI NOOR MOHAMMAD; TEIMOURI ALIREZA; Nakhaey Moghaddam Maryam

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Journal: Journal of Pediatric Perspectives Year:2017 | Volume:5 | Issue:11 (47) Page(s): 6077-6094

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Title

Diagnostic Value of NT-pro BNP Biomarker and Echocardiography in Cardiac Involvements in Beta-thalassemia Patients

Author(s)

NOORI NOOR MOHAMMAD | TEIMOURI ALIREZA | Nakhaey Moghaddam Maryam | Issue Writer Certificate

Keywords

Key Words:Children

Cardiac involvement

Echocardiography

NT-pro BNP

Beta-thalassemia

Abstract

Background N-terminal pro– B-type natriuretic peptide (NT-proBNP) is a marker to evaluate the Cardiac involvement in thalassemia. We aimed to evaluate conventional and tissue Doppler Echocardiography findings and its relation to plasma NT-pro BNP, Ferritin and Iron levels in Beta-thalassemia patients. Materials and Methods This study performed on 164 participants equal of major Beta-thalassemia patients (n=82), and controls (82 healthy children with normal cardiovascular status). The patients collected from outpatients after applied exclusion criteria. Blood samples were taken from participants in fasting to measure NT-pro BNP, Ferritin and Iron serum. Participants were under Echocardiography by Pediatric cardiologist. The level of error considered as 0. 05 for data analysis by SPSS version 20. 0. Results NT-pro BNP, Iron, Ferritin, left S', left A', right A', EF, FS, left and right A/A'; right and left MPI were significantly different in patients group (P<0. 05). FS and EF were higher in younger’ s and left and right MPI were lower. In higher level of NT-pro BNP right S' had converse trends compared with the Iron, its level was higher in patients > 10 years, and FS had different values significantly in lower levels. In lower level of left E/E' resulted that FS was significantly higher in the age group < 10 years. Right peak E velocity was significantly higher in younger’ s in higher level of left E/E'. Right E/E' was significantly higher in elders in lower level of left E/E' (P<0. 05). Conclusion The study confirmed that NT-pro BNP increases in thalassemia and association with age and LV diastolic dysfunction. NT-pro BNP with E/E' and S' were shown diastolic and systolic dysfunction in thalassemia. Therefore, an increased level of ferritin and NT-pro BNP can be used as a marker for the intensification of iron chelation therapy, which reverses iron-induced cardiomyopathy.

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APA: Copy

NOORI, NOOR MOHAMMAD, TEIMOURI, ALIREZA, & Nakhaey Moghaddam, Maryam. (2017). Diagnostic Value of NT-pro BNP Biomarker and Echocardiography in Cardiac Involvements in Beta-thalassemia Patients. INTERNATIONAL JOURNAL OF PEDIATRICS, 5(11 (47)), 6077-6094. SID. https://sid.ir/paper/337768/en

Vancouver: Copy

NOORI NOOR MOHAMMAD, TEIMOURI ALIREZA, Nakhaey Moghaddam Maryam. Diagnostic Value of NT-pro BNP Biomarker and Echocardiography in Cardiac Involvements in Beta-thalassemia Patients. INTERNATIONAL JOURNAL OF PEDIATRICS[Internet]. 2017;5(11 (47)):6077-6094. Available from: https://sid.ir/paper/337768/en

IEEE: Copy

NOOR MOHAMMAD NOORI, ALIREZA TEIMOURI, and Maryam Nakhaey Moghaddam, “Diagnostic Value of NT-pro BNP Biomarker and Echocardiography in Cardiac Involvements in Beta-thalassemia Patients,” INTERNATIONAL JOURNAL OF PEDIATRICS, vol. 5, no. 11 (47), pp. 6077–6094, 2017, [Online]. Available: https://sid.ir/paper/337768/en

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