Study of Polymorphism of the DRD2 Gene (-141C Ins/Del, rs1799732) with Attention Deficit Hyperactivity Disorder a Population Sample of Children in Iranian-Azeri

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MEHDIZADEH FANID LEILA; ADAMPOUREZARE MINA; HOSSEINPOUR FEIZI MOHAMMAD ALI; Noorazar Gholamreza

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Journal: Journal of Pediatric Perspectives Year:2017 | Volume:5 | Issue:3 (39) Page(s): 4569-4574

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Title

Study of Polymorphism of the DRD2 Gene (-141C Ins/Del, rs1799732) with Attention Deficit Hyperactivity Disorder a Population Sample of Children in Iranian-Azeri

Author(s)

MEHDIZADEH FANID LEILA | ADAMPOUREZARE MINA | HOSSEINPOUR FEIZI MOHAMMAD ALI | Noorazar Gholamreza | Issue Writer Certificate

Keywords

ADHD

DRD2 gene

Iranian children

Polymorphism

Abstract

Background Attention deficit hyperactivity disorder (ADHD), is a multifactorial disorder and converging evidence has implicated abnormalities of dopamine neurotransmission. The aim of this study was to examine the association of-141 Polymorphisms in DRD2 gene with ADHA among Iranian-Azeri population. Materials and Methods A case– control association study included 153 patients with attention deficit hyper activity disorder (case group), and 133 healthy subjects (control group). Genomic DNA was extracted peripheral blood samples by salting-out method. Single nucleotide Polymorphism (SNP) genotyping was performed by Polymerase chain reaction-restriction fragment length Polymorphism (PCR-RFLP) technique. The data analysis was performed through Chi-square, with a significance level of 0. 05. Results: There was not significant difference in the allele and genotype frequencies between ADHD and-141C Ins/Del Polymorphism in cases and controls (P>0. 05). Ins/Ins homozygous dominants were more frequent in control group than the case group, but there was not significant difference observed (P>0. 05). Del/Del homozygous dominants were not observed. No significant difference was detected in the allele and genotype frequencies between ADHD and-141 Insertion/Deletion Polymorphism in cases and control groups (P>0. 05). Conclusion Our results do not detected association between the-141C Ins/Del, rs1799732, Polymorphism and ADHD disorder in population of Children in Iranian-Azeri.

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APA: Copy

MEHDIZADEH FANID, LEILA, ADAMPOUREZARE, MINA, HOSSEINPOUR FEIZI, MOHAMMAD ALI, & Noorazar, Gholamreza. (2017). Study of Polymorphism of the DRD2 Gene (-141C Ins/Del, rs1799732) with Attention Deficit Hyperactivity Disorder a Population Sample of Children in Iranian-Azeri. INTERNATIONAL JOURNAL OF PEDIATRICS, 5(3 (39)), 4569-4574. SID. https://sid.ir/paper/337915/en

Vancouver: Copy

MEHDIZADEH FANID LEILA, ADAMPOUREZARE MINA, HOSSEINPOUR FEIZI MOHAMMAD ALI, Noorazar Gholamreza. Study of Polymorphism of the DRD2 Gene (-141C Ins/Del, rs1799732) with Attention Deficit Hyperactivity Disorder a Population Sample of Children in Iranian-Azeri. INTERNATIONAL JOURNAL OF PEDIATRICS[Internet]. 2017;5(3 (39)):4569-4574. Available from: https://sid.ir/paper/337915/en

IEEE: Copy

LEILA MEHDIZADEH FANID, MINA ADAMPOUREZARE, MOHAMMAD ALI HOSSEINPOUR FEIZI, and Gholamreza Noorazar, “Study of Polymorphism of the DRD2 Gene (-141C Ins/Del, rs1799732) with Attention Deficit Hyperactivity Disorder a Population Sample of Children in Iranian-Azeri,” INTERNATIONAL JOURNAL OF PEDIATRICS, vol. 5, no. 3 (39), pp. 4569–4574, 2017, [Online]. Available: https://sid.ir/paper/337915/en

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