مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Cites:

1

Information Journal Paper

Title

COMPARISON OF ORAL MIDAZOLAM AND PROMETHAZINE WITH ORAL MIDAZOLAM ALONE FOR SEDATING CHILDREN DURING COMPUTED TOMOGRAPHY

Pages

  109-113

Abstract

 Introduction: Both MIDAZOLAM and PROMETHAZINE are recommended to be used as sedatives in many studies but each have some side effects that limits their use. Combination therapy as an alternative method, may decreases these limitations. Therefore, this study aimed to compare MIDAZOLAM with MIDAZOLAM-PROMETHAZINE regarding induction, maintenance, and recovery characteristics following pediatric procedural sedation and analgesia.Methods: Children under 7 years old who needed sedation for being CT scanned were included in this double-blind randomized clinical trial. The patients were randomly divided into 2 groups: one only received MIDAZOLAM (0.5 mg/kg), while the other group received a combination of MIDAZOLAM (0.5 mg/kg) and PROMETHAZINE (1.25 mg/kg). University of Michigan Sedation Scale (UMSS) was used to assess sedation induction. In addition to demographic data, the child’s vital signs were evaluated before prescribing the drugs and after inducing sedation (reaching UMSS level 2). The primary outcomes in the present study were onset of action after administration and duration of the drugs’ effect.Results: 107 patients were included in the study. Mean onset of action was 55.4±20.3 minutes for MIDAZOLAM and 32.5±11.1 minutes for MIDAZOLAM-PROMETHAZINE combination (p<0.001). But duration of effect was not different between the 2 groups (p=0.36). 8 (7.5%) patients were unresponsive to the medication, all 8 of which were in the MIDAZOLAM treated group (p=0.006). Also in 18 (16.8%) cases a rescue dose was prescribed, 14 (25.9%) were in the MIDAZOLAM group and 4 (7.5%) were in the MIDAZOLAM-PROMETHAZINE group (p=0.02). Comparing systolic (p=0.20) and diastolic (p=0.34) blood pressure, heart rate (p=0.16), respiratory rate (p=0.17) and arterial oxygen saturation level (p=0.91) showed no significant difference between the 2 groups after intervention. Conclusion: Based on the findings of this study, it seems that using a combination of MIDAZOLAM and PROMETHAZINE not only speeds up the sedation induction, but also decreases unresponsiveness to the treatment and the need for a rescue dose.

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    APA: Copy

    BARZEGARI, HASSAN, ZOHREVANDI, BEHZAD, MASOUMI, KAMBIZ, FOROUZAN, ARASH, ASGARI DARIAN, ALI, & KHOSRAVI, SHAGHAYEGH. (2015). COMPARISON OF ORAL MIDAZOLAM AND PROMETHAZINE WITH ORAL MIDAZOLAM ALONE FOR SEDATING CHILDREN DURING COMPUTED TOMOGRAPHY. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), 3(3), 109-113. SID. https://sid.ir/paper/339578/en

    Vancouver: Copy

    BARZEGARI HASSAN, ZOHREVANDI BEHZAD, MASOUMI KAMBIZ, FOROUZAN ARASH, ASGARI DARIAN ALI, KHOSRAVI SHAGHAYEGH. COMPARISON OF ORAL MIDAZOLAM AND PROMETHAZINE WITH ORAL MIDAZOLAM ALONE FOR SEDATING CHILDREN DURING COMPUTED TOMOGRAPHY. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY)[Internet]. 2015;3(3):109-113. Available from: https://sid.ir/paper/339578/en

    IEEE: Copy

    HASSAN BARZEGARI, BEHZAD ZOHREVANDI, KAMBIZ MASOUMI, ARASH FOROUZAN, ALI ASGARI DARIAN, and SHAGHAYEGH KHOSRAVI, “COMPARISON OF ORAL MIDAZOLAM AND PROMETHAZINE WITH ORAL MIDAZOLAM ALONE FOR SEDATING CHILDREN DURING COMPUTED TOMOGRAPHY,” ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), vol. 3, no. 3, pp. 109–113, 2015, [Online]. Available: https://sid.ir/paper/339578/en

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