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Title

Low-Dose Fentanyl, Propofol, Midazolam, Ketamine and Lidocaine Combination vs. Regular Dose Propofol and Fentanyl Combination for Deep Sedation Induction; a Randomized Clinical Trial

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Abstract

 Introduction: Need for procedural sedation and analgesia (PSA) is felt in emergency department (ED) more and more each day. This study aimed to compare the effectiveness of low-dose fentanyl, propofol, midazolam, ketamine and lidocaine combination with regular dose of propofol and fentanyl combination for induction of deep sedation. Methods: In this single-blind Clinical trial, candidate patients for sedation and analgesia aged more than 15 and less than 60 years old, with pain score ¸ 6 were allocated to one of the groups using block randomization and were compared regarding onset of action, recovery time, and probable side effects. Results: 125 patients with the mean age of 37. 8 § 14. 3 years were randomly allocated to each group. 100% of the patients in group 1 (5 drugs) and 56. 5% of the patients in group 2 (2 drugs) were deeply sedated in the 3rd minute after injection. The 2 groups were significantly different regarding onset of action (p = 0. 440), recovery time (p = 0. 018), and treatment failure (p < 0. 001). Conclusion: Low-dose fentanyl, propofol, midazolam, ketamine and lidocaine combination was more successful in induction of deep sedation compared to regular dose of propofol and fentanyl combination. Recovery time was a little longer in this group and both groupswere similar regarding drug side effects and effect on vital signs.

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    APA: Copy

    AMINI, AFSHIN, ARHAMI DOLATABADI, ALI, KARIMAN, HAMID, HATAMABADI, HAMIDREZA, MEMARY, ELHAM, SALIMI, SOHRAB, & Shokrzadeh, Shahram. (2018). Low-Dose Fentanyl, Propofol, Midazolam, Ketamine and Lidocaine Combination vs. Regular Dose Propofol and Fentanyl Combination for Deep Sedation Induction; a Randomized Clinical Trial. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), 6(1), 0-0. SID. https://sid.ir/paper/339654/en

    Vancouver: Copy

    AMINI AFSHIN, ARHAMI DOLATABADI ALI, KARIMAN HAMID, HATAMABADI HAMIDREZA, MEMARY ELHAM, SALIMI SOHRAB, Shokrzadeh Shahram. Low-Dose Fentanyl, Propofol, Midazolam, Ketamine and Lidocaine Combination vs. Regular Dose Propofol and Fentanyl Combination for Deep Sedation Induction; a Randomized Clinical Trial. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY)[Internet]. 2018;6(1):0-0. Available from: https://sid.ir/paper/339654/en

    IEEE: Copy

    AFSHIN AMINI, ALI ARHAMI DOLATABADI, HAMID KARIMAN, HAMIDREZA HATAMABADI, ELHAM MEMARY, SOHRAB SALIMI, and Shahram Shokrzadeh, “Low-Dose Fentanyl, Propofol, Midazolam, Ketamine and Lidocaine Combination vs. Regular Dose Propofol and Fentanyl Combination for Deep Sedation Induction; a Randomized Clinical Trial,” ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), vol. 6, no. 1, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/339654/en

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