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Title

Laboratory Parameters in Detection of COVID-19 Patients with Positive RT-PCR; a Diagnostic Accuracy Study

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Abstract

 Introduction: The role of laboratory parameters in screening of COVID-19 cases has not been definitely established. This study aimed to evaluate the accuracy of laboratory parameters in predicting cases with positive RT-PCR for COVID-19. Methods: This diagnostic accuracy study was conducted on suspected COVID-19 patients, who presented to Behpooyan ClinicMedical center in Tehran (Iran) from 22 February to 14March, 2020. Patients were divided into two groups based on the results of real time reverse transcriptase-polymerase chain reaction (RT-PCR) for COVID-19, and the accuracy of different laboratory parameters in predicting cases with positive RT-PCR was evaluated using area under the ROC curve (AUC). Results: Two hundred cases with the mean age of 41. 3§ 14. 6 (range: 19-78) years were studied (0. 53% male). The result of RT-PCR for COVID-19 was positive in 70 (35%) cases. Patients with positive RT-PCR had significantly higher neutrophil (NEU) count (p = 0. 0001), and C-reactive protein (CRP) (p = 0. 04), lactate dehydrogenase (LDH) (p = 0. 0001), aspartate aminotransferase (AST) (p = 0. 001), alanine aminotransferase (ALT) (p = 0. 0001), and Urea (p = 0. 001) levels in serum. In addition, patients with positive RT-PCR had lower white blood cell (WBC) count (p = 0. 0001) and serum albumin level (p = 0. 0001) compared to others. ALT (AUC = 0. 879), CRP (AUC = 0. 870), NEU (AUC = 0. 858), LDH (AUC = 0. 835), and Urea (AUC = 0. 835) had very good accuracy in predicting cases with positive RT-PCR for COVID-19, respectively. Conclusion: Our findings suggest that level of LDH, CRP, ALT and NEU can be used to predict the result of COVID-19 test. They can help in detection of COVID-19 patients.

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APA: Copy

Mardani, Rajab, AHMADI VASMEHJANI, ABBAS, Zali, Fatemeh, GHOLAMI, ALIREZA, MOUSAVI NASAB, SEYED DAWOOD, Kaghazian, Hooman, Kaviani, mehdi, & AHMADI, NAYEBALI. (2020). Laboratory Parameters in Detection of COVID-19 Patients with Positive RT-PCR; a Diagnostic Accuracy Study. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), 8(1), 0-0. SID. https://sid.ir/paper/339867/en

Vancouver: Copy

Mardani Rajab, AHMADI VASMEHJANI ABBAS, Zali Fatemeh, GHOLAMI ALIREZA, MOUSAVI NASAB SEYED DAWOOD, Kaghazian Hooman, Kaviani mehdi, AHMADI NAYEBALI. Laboratory Parameters in Detection of COVID-19 Patients with Positive RT-PCR; a Diagnostic Accuracy Study. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY)[Internet]. 2020;8(1):0-0. Available from: https://sid.ir/paper/339867/en

IEEE: Copy

Rajab Mardani, ABBAS AHMADI VASMEHJANI, Fatemeh Zali, ALIREZA GHOLAMI, SEYED DAWOOD MOUSAVI NASAB, Hooman Kaghazian, mehdi Kaviani, and NAYEBALI AHMADI, “Laboratory Parameters in Detection of COVID-19 Patients with Positive RT-PCR; a Diagnostic Accuracy Study,” ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), vol. 8, no. 1, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/339867/en

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