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Information Journal Paper

Title

Accuracy of Urine Kidney Injury Molecule-1 in Predicting Acute Kidney Injury in Children; a Systematic Review and Meta-Analysis

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  0-0

Abstract

 Introduction: There is considerable controversy on the accuracy of Kidney InjuryMolecule-1 (KIM-1) in prediction of Acute Kidney Injury (AKI) in children. Therefore, the present study intends to provide a systematic review and meta-analysis of the value of this biomarker in predicting AKI in children. Methods: An extensive search was performed on the Medline, Embase, Scopus and Web of Science databases by the end of 2019. Cohort and case-control studies on children were included. Urinary KIM-1 levels were compared between AKI and non-AKI groups. Findings were reported as an overall standardized mean difference (SMD) with a 95% confidence interval (CI). Also, the overall area under the receiver operating characteristic (ROC) curve (AUC) of KIM-1 in predicting AKI in children was calculated. Results: Data from 13 articles were included. Urinary KIM-1 levels in children with stage 1 AKI were higher than the non-AKI group only when assessed within the first 12 hours after admission (SMD = 0. 95; 95% CI: 0. 07 to 1. 84; p = 0. 034). However, urinary KIM-1 levels in children with stage 2-3 AKI were significantly higher than non-AKI children (p <0. 01) at all times. The AUC of urinary KIM-1 in predicting AKI in children was 0. 69 (95% CI: 0. 62 to 0. 77). Conclusion: Based on the available evidence, KIM-1 seems to have moderate value in predicting AKI in children. Since previous meta-analyses have provided other urinary and serum biomarkers that have better discriminatory accuracy than KIM-1, so it had better not to use KIM-1 in predicting AKI in children.

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    APA: Copy

    FAZEL, MOJTABA, SARVEAZAD, ARASH, Mohamed Ali, Kosar, YOUSEFIFARD, MAHMOOD, & HOSSEINI, MOSTAFA. (2020). Accuracy of Urine Kidney Injury Molecule-1 in Predicting Acute Kidney Injury in Children; a Systematic Review and Meta-Analysis. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), 8(1), 0-0. SID. https://sid.ir/paper/339871/en

    Vancouver: Copy

    FAZEL MOJTABA, SARVEAZAD ARASH, Mohamed Ali Kosar, YOUSEFIFARD MAHMOOD, HOSSEINI MOSTAFA. Accuracy of Urine Kidney Injury Molecule-1 in Predicting Acute Kidney Injury in Children; a Systematic Review and Meta-Analysis. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY)[Internet]. 2020;8(1):0-0. Available from: https://sid.ir/paper/339871/en

    IEEE: Copy

    MOJTABA FAZEL, ARASH SARVEAZAD, Kosar Mohamed Ali, MAHMOOD YOUSEFIFARD, and MOSTAFA HOSSEINI, “Accuracy of Urine Kidney Injury Molecule-1 in Predicting Acute Kidney Injury in Children; a Systematic Review and Meta-Analysis,” ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), vol. 8, no. 1, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/339871/en

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