Metronidazole; a Potential Novel Addition to the COVID-19 Treatment Regimen

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Gharebaghi Alireza; HEIDARY FATEMEH; MORADI MOHAMMAD; PARVIZI MARYAM

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Archives of Academic Emergency Medicine Year:2020 | Volume:8 | Issue:1 Page(s): 0-0

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Information Journal Paper

Title

Metronidazole; a Potential Novel Addition to the COVID-19 Treatment Regimen

Author(s)

Gharebaghi Alireza | HEIDARY FATEMEH | MORADI MOHAMMAD | PARVIZI MARYAM | Issue Writer Certificate

Keywords

Coronavirus disease

COVID-19

Metronidazole

Cytokines

Interleukins

Abstract

Coronavirus disease 2019 or COVID-19 has rapidly emerged as a global pandemic. This viral infection involves the upper respiratory tract and could lead to severe pneumonia with respiratory distress or even death. Certain studies have found higher initial plasma levels of most pro-inflammatory Cytokines during the course of the infection. In this context, both in vitro and in vivo studies have revealed that Metronidazole could decrease the levels of several Cytokines, which are known to increase during the COVID-19 infection, including interleukin (IL)8, IL6, IL1B, tumor necrosis factor (TNF)® , IL12, IL1® , and interferon (IFN)° , as well as the levels of C-reactive protein (CRP) and neutrophil count. Furthermore, the drug could decrease neutrophil-generated reactive oxygen species during inflammation. Metronidazole could counteract majority of the immunopathological manifestations of the COVID-19 infection. Therefore, studies with a large sample size are required to determine the efficacy of Metronidazole in the treatment of COVID-19 infection.

Cites

COVID-19: Preliminary Clinical Guidelines for Ophthalmology Practices

References

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APA: Copy

Gharebaghi, Alireza, HEIDARY, FATEMEH, MORADI, MOHAMMAD, & PARVIZI, MARYAM. (2020). Metronidazole; a Potential Novel Addition to the COVID-19 Treatment Regimen. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), 8(1), 0-0. SID. https://sid.ir/paper/339873/en

Vancouver: Copy

Gharebaghi Alireza, HEIDARY FATEMEH, MORADI MOHAMMAD, PARVIZI MARYAM. Metronidazole; a Potential Novel Addition to the COVID-19 Treatment Regimen. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY)[Internet]. 2020;8(1):0-0. Available from: https://sid.ir/paper/339873/en

IEEE: Copy

Alireza Gharebaghi, FATEMEH HEIDARY, MOHAMMAD MORADI, and MARYAM PARVIZI, “Metronidazole; a Potential Novel Addition to the COVID-19 Treatment Regimen,” ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), vol. 8, no. 1, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/339873/en

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