THE EFFICACY OF KETAMINE ADMINISTRATION IN PREHOSPITAL PAIN MANAGEMENT OF TRAUMA PATIENTS; A SYSTEMATIC REVIEW AND META-ANALYSIS

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YOUSEFIFARD MAHMOUD; Askarian Amiri Shaghayegh; Rafiei Alavi Seyedeh Niloufar; SADEGHI MOSTAFA; SABERIAN PEYMAN; BARATLOO ALIREZA; TALEBIAN MOHAMMAD TAGHI

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Journal: Archives of Academic Emergency Medicine Year:2020 | Volume:8 | Issue:1 Page(s): 0-0

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Title

THE EFFICACY OF KETAMINE ADMINISTRATION IN PREHOSPITAL PAIN MANAGEMENT OF TRAUMA PATIENTS; A SYSTEMATIC REVIEW AND META-ANALYSIS

Author(s)

Keywords

PAINMANAGEMENT

ANALGESICS

OPIOID

ANALGESICS

NON-NARCOTIC

EMERGENCYMEDICAL SERVICES

KETAMINE

Abstract

Although previous articles and reviews suggest that KETAMINE might effectively manage pain in trauma patients, these articles have serious limitations. Accordingly, the current meta-analysis aims to investigate the efficacy of KETAMINE administration in prehospital pain management of trauma patients. Method: In the present meta-analysis, controlled human studies were included. An extensive search was conducted in electronic databases including Medline (via PubMed), Embase, Central, Scopus, Web of Science, and ProQuest, gathering data to the end of 2018. The efficacy and side effects of KETAMINE administration in pre-hospital pain management were compared with those of OPIOID ANALGESICS based on standard mean difference (SMD) and odds ratio (OR) calculations with 95% confidence interval (95% CI). Results: Data from seven articles were included in the presentmeta-analysis. KETAMINE administration was not more effective than administrating morphine or fentanyl in prehospital pain management of trauma patients (SMD =-0. 56, 95% CI:-1. 38 to 0. 26, p = 0. 117). However, co-administration of KETAMINE+morphine was considerably more effective than KETAMINE alone, in alleviating pain in prehospital settings (SMD =-0. 62, 95% CI:-1. 12 to-0. 12, p = 0. 010). Finally, it was concluded that KETAMINE alone had less side effects than morphine alone (OR = 0. 25, 95% CI: 0. 11 to 0. 56, p = 0. 001). However, co-administration of KETAMINE+morphine increases the risk of side effects to 3. 68 times compared to when morphine is prescribed solely (OR=3. 68, 95% CI: 1. 99 to 6. 82, p<0. 001). Conclusion: For the first time, findings of the current meta-analysis demonstrated that KETAMINE, being administered alone, is an effective and safe medication in prehospital pain management in trauma patients, and can be considered as an acceptable alternative to OPIOID ANALGESICS.

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APA: Copy

YOUSEFIFARD, MAHMOUD, Askarian Amiri, Shaghayegh, Rafiei Alavi, Seyedeh Niloufar, SADEGHI, MOSTAFA, SABERIAN, PEYMAN, BARATLOO, ALIREZA, & TALEBIAN, MOHAMMAD TAGHI. (2020). THE EFFICACY OF KETAMINE ADMINISTRATION IN PREHOSPITAL PAIN MANAGEMENT OF TRAUMA PATIENTS; A SYSTEMATIC REVIEW AND META-ANALYSIS. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), 8(1), 0-0. SID. https://sid.ir/paper/339885/en

Vancouver: Copy

YOUSEFIFARD MAHMOUD, Askarian Amiri Shaghayegh, Rafiei Alavi Seyedeh Niloufar, SADEGHI MOSTAFA, SABERIAN PEYMAN, BARATLOO ALIREZA, TALEBIAN MOHAMMAD TAGHI. THE EFFICACY OF KETAMINE ADMINISTRATION IN PREHOSPITAL PAIN MANAGEMENT OF TRAUMA PATIENTS; A SYSTEMATIC REVIEW AND META-ANALYSIS. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY)[Internet]. 2020;8(1):0-0. Available from: https://sid.ir/paper/339885/en

IEEE: Copy

MAHMOUD YOUSEFIFARD, Shaghayegh Askarian Amiri, Seyedeh Niloufar Rafiei Alavi, MOSTAFA SADEGHI, PEYMAN SABERIAN, ALIREZA BARATLOO, and MOHAMMAD TAGHI TALEBIAN, “THE EFFICACY OF KETAMINE ADMINISTRATION IN PREHOSPITAL PAIN MANAGEMENT OF TRAUMA PATIENTS; A SYSTEMATIC REVIEW AND META-ANALYSIS,” ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), vol. 8, no. 1, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/339885/en

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