3-Month Outcome of Ischemic Stroke Patients Underwent Thrombolytic Therapy; a Cohort Study

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SARIASLANI PAYAM; REZAEIAN SHAHAB; Safari Elham

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Journal: Archives of Academic Emergency Medicine Year:2020 | Volume:8 | Issue:1 Page(s): 0-0

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Title

3-Month Outcome of Ischemic Stroke Patients Underwent Thrombolytic Therapy; a Cohort Study

Author(s)

SARIASLANI PAYAM | REZAEIAN SHAHAB | Safari Elham | Issue Writer Certificate

Keywords

Tissue plasminogen activator

stroke

brain ischemia

stroke rehabilitation

Abstract

Introduction: Reperfusion and neuroprotection are 2 main treatment strategies exist for management of patients with ischemic stroke. This study aimed to assess the 3-month outcome of patientswho underwent thrombolytic therapy following ischemic stroke. Methods: In the present prospective cohort study, the 3-month outcome of patients (mortality, disability) with acute ischemic stroke admitted to neurology department an educational hospital, Kermanshah, Iran, from 2016 to 2019, who had received thrombolytic therapy was assessed. National Institute of Health Stroke Scale (NIHSS) and Modified Rankin Score (MRS) were used for measuring the degree of disability (on admission, at the time of discharge and 3 months after thrombolytic therapy). Results: 217 patients with the mean age of 66. 40 § 13. 37 (27 – 97) years were studied (55. 3% male). There was no significant correlation between decrease in NIHSS score and age (p = 0. 44), sex (p = 0. 082), time interval between initiation of symptoms (p = 0. 104), and blood pressure on admission (p = 0. 156). However, patients with blood sugar lower than 144 had better 3-month outcome (p = 0. 045). Additionally, there was no significant correlation between the rate of decrease in MRS score and age (p = 0. 813), sex (p = 0. 875), time interval between initiation of symptoms (p = 0. 495), and blood pressure on admission (p = 0. 264). However, patients with blood sugar lower than 144 had better 3-month outcome (p = 0. 022). 47 (21. 7%) patient died and 170 (78. 3%) were discharged. Mean age of the patients who died (73. 70 § 11. 85 versus 64. 39 § 13. 09 years; p < 0. 0001) and their NIHSS score on admission (13. 22 § 6. 01 versus 11. 28 § 5. 70; p = 0. 045) were significantly higher. In other words, the odds of mortality was 3. 19 times in patients over 60 years of age (95% confidence interval (CI): 1. 18 – 8. 62) and 1. 83 times in patients with NIHSS score over 12 (95% CI: 0. 92 – 3. 61). Conclusion: There was no significant correlation between 3-month disabilities of stroke patients underwent thrombolytic therapy and age, sex, time from initiation of symptoms, or vital signs on admission. Patients with a blood sugar lower than 144 had better 3-month outcome.

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References

Intravenous thrombolysis for acute ischemic stroke: review of 97 patients

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APA: Copy

SARIASLANI, PAYAM, REZAEIAN, SHAHAB, & Safari, Elham. (2020). 3-Month Outcome of Ischemic Stroke Patients Underwent Thrombolytic Therapy; a Cohort Study. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), 8(1), 0-0. SID. https://sid.ir/paper/339886/en

Vancouver: Copy

SARIASLANI PAYAM, REZAEIAN SHAHAB, Safari Elham. 3-Month Outcome of Ischemic Stroke Patients Underwent Thrombolytic Therapy; a Cohort Study. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY)[Internet]. 2020;8(1):0-0. Available from: https://sid.ir/paper/339886/en

IEEE: Copy

PAYAM SARIASLANI, SHAHAB REZAEIAN, and Elham Safari, “3-Month Outcome of Ischemic Stroke Patients Underwent Thrombolytic Therapy; a Cohort Study,” ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), vol. 8, no. 1, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/339886/en

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