INSULIN-LIKE GROWTH FACTOR I (IGF-I) IN THALASSEMIA MAJOR AND ITS RELATIONSHIP WITH BONE MINERAL DENSITY AND PUBERTY

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TABATABAEI S.M.; KAMGHAR M.; ABDOLLAH SHAMSHIRSAZ A.; BAKHIRNIA M.R.; HABIBZADEH M.R.; ABDOLLAH SHAMSHIRSAZ A.H.; ARDESHIR LARIJANI MOHAMMAD BAGHER

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Journal: Iranian South Medical Journal Year:2002 | Volume:5 | Issue:1 Page(s): 8-16

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Title

INSULIN-LIKE GROWTH FACTOR I (IGF-I) IN THALASSEMIA MAJOR AND ITS RELATIONSHIP WITH BONE MINERAL DENSITY AND PUBERTY

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Keywords

THALASSEMIAQ3

PUBERTYQ3

IGF-1Q2

BMDQ3

Abstract

Background: Insulin-like growth factor 1(IGF-1) has an important role in growth as well as bone formation. There are reports that patient with ß THALASSEMIA frequently have low IGF-1 level. In this study, we assessed the IGF1 status and its relationship to PUBERTY and Bone Mineral Density (BMD) disturbance in a group of thalassemic patients.Subjects and methods: 206 thalassemics and 229 healthy controls, aged 10-20 years were entered the study. Serum IGF1 level was determined in all participants by RIA. BMD was measured by dual-energy x-ray absorptiometry(DXA).Result: Serum IGF-1 and BMD values at both lumbar and femoral neck regions were lower in thalassemics. Serum IGF1 in 27.9 % of thalassemics (30.4% in boys, 25.3% in girls) was 2 standard deviation (SD) below that of age-sex matched controls; this was more frequent in those in PUBERTY stages I, IIand III (based on Marshal Tanner) in comparison with those in stages IV and V (30.8% vs 8.7%, p=0.027). Higher lGF1 level was observed in pubertal (Tanner stage>1) compared to pre-pubertal (Tanner stage I) thalassemic girls (p=0.013) but this was not the case In thalassemic boys. In thalassemic patients, Z-scores of BMD at lumbar and femoral regions were below -2 in 65.8% and 15.6%, respectively (p<0.05). Z-score of lumbar BMD below -2 was more frequent in thalassemic boys (73.3% in males vs 57.4% in females, p=0.018). A positive correlation existed between IGF-1 SDs and BMD Z-score of lumbar spine in Tanner stages III (r = 0.316, p = 0.027) and IV (r = 0.519, p= 0.027).Conclusion: Serum IGF-1 is low in THALASSEMIA major. It has positive correlation with bone mineral density in higher stages of PUBERTY in these patients. Therefore, IGF-1 is an important factor in bone mineralization in conjunction with steroidal hormones.

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APA: Copy

TABATABAEI, S.M., KAMGHAR, M., ABDOLLAH SHAMSHIRSAZ, A., BAKHIRNIA, M.R., HABIBZADEH, M.R., ABDOLLAH SHAMSHIRSAZ, A.H., & ARDESHIR LARIJANI, MOHAMMAD BAGHER. (2002). INSULIN-LIKE GROWTH FACTOR I (IGF-I) IN THALASSEMIA MAJOR AND ITS RELATIONSHIP WITH BONE MINERAL DENSITY AND PUBERTY. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), 5(1), 8-16. SID. https://sid.ir/paper/34122/en

Vancouver: Copy

TABATABAEI S.M., KAMGHAR M., ABDOLLAH SHAMSHIRSAZ A., BAKHIRNIA M.R., HABIBZADEH M.R., ABDOLLAH SHAMSHIRSAZ A.H., ARDESHIR LARIJANI MOHAMMAD BAGHER. INSULIN-LIKE GROWTH FACTOR I (IGF-I) IN THALASSEMIA MAJOR AND ITS RELATIONSHIP WITH BONE MINERAL DENSITY AND PUBERTY. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ)[Internet]. 2002;5(1):8-16. Available from: https://sid.ir/paper/34122/en

IEEE: Copy

S.M. TABATABAEI, M. KAMGHAR, A. ABDOLLAH SHAMSHIRSAZ, M.R. BAKHIRNIA, M.R. HABIBZADEH, A.H. ABDOLLAH SHAMSHIRSAZ, and MOHAMMAD BAGHER ARDESHIR LARIJANI, “INSULIN-LIKE GROWTH FACTOR I (IGF-I) IN THALASSEMIA MAJOR AND ITS RELATIONSHIP WITH BONE MINERAL DENSITY AND PUBERTY,” IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), vol. 5, no. 1, pp. 8–16, 2002, [Online]. Available: https://sid.ir/paper/34122/en

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