NONINVASIVE REST AND ACETAZOLAMIDE BRAIN PERFUSION ONE – DAY PROTOCOL USING SPECT/CT

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BINH DANG AN; HANG BUI DIEU; TOAN TRAN SONG; TRI TRAN MINH; QUYNH VY TRAN VU; ISHIGURO MASSANOBU; TOYAMA HIROSHI

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Journal: Asia Oceania Journal of Nuclear Medicine & Biology Year:2014 | Volume:2 | Issue:SUPPLEMENT 1 Page(s): 49-49

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Title

NONINVASIVE REST AND ACETAZOLAMIDE BRAIN PERFUSION ONE – DAY PROTOCOL USING SPECT/CT

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Abstract

Background: Brain perfusion SPECT imaging has been a useful way to evaluate cerebro‐vascular diseases and other neuro diseases. Two‐day protocol brain perfusion SPECT is more accurate but not convenient for most patients. This is the reason why a one – day protocol using SPECT/CT was designed.Materials and Methods: Both rest and acetazolamide was done by SPECT/CT system. A 2 minute ‐ dynamic acquisition was carried out immediately after injection of 99mTc ‐ HMPAO. Then, the 1st rest SPECT study was done for 30 min after 3 min post injection of 370 MBq (10 mCi) of 99mTc ‐ HMPAO. Immediately after the 1st SPECT, 1g of acetazolamide was given intravenously. Ten minutes later, 740 MBq (20 mCi) of 99mTc – HMPAO was additionally injected. Three minutes later the 2nd SPECT study was carried out for 30 min. To measure regional cerebral blood flow (rCBF) non‐invasively, the Patlak plot analysis was applied to time–activity data on radionuclide angiography. Then reconstructed images from 1st SPECT were converted to 1st rCBF map. Base on the increased count ratio in cerebellum between decay corrected 1st and 2nd SPECT images, acetazolamide increasing ratio was calculated, and then 2nd rCBF map was generated. Region of interest (ROI) in 1st and 2nd images were set, then %increase values were calculated.Results: Thirty‐three patients were performed. The rest cortices showed rCBF values by 49.3±3.3 ml/100g brain/min, acetazolamide enhanced cortices show rCBF values by 53.8±4.0 ml/100g brain/min and % increase value by 8.9±3.7 on average.Conclusion: This method of imaging would be significant for evaluating cerebral perfusion reserve in the routine cerebro‐vascular disease for a comfortable method to patient because they do not have to come to hospital in 2 days for scanning.

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APA: Copy

BINH, DANG AN, HANG, BUI DIEU, TOAN, TRAN SONG, TRI, TRAN MINH, QUYNH VY, TRAN VU, ISHIGURO, MASSANOBU, & TOYAMA, HIROSHI. (2014). NONINVASIVE REST AND ACETAZOLAMIDE BRAIN PERFUSION ONE – DAY PROTOCOL USING SPECT/CT. ASIA OCEANIA JOURNAL OF NUCLEAR MEDICINE AND BIOLOGY, 2(SUPPLEMENT 1), 49-49. SID. https://sid.ir/paper/342059/en

Vancouver: Copy

BINH DANG AN, HANG BUI DIEU, TOAN TRAN SONG, TRI TRAN MINH, QUYNH VY TRAN VU, ISHIGURO MASSANOBU, TOYAMA HIROSHI. NONINVASIVE REST AND ACETAZOLAMIDE BRAIN PERFUSION ONE – DAY PROTOCOL USING SPECT/CT. ASIA OCEANIA JOURNAL OF NUCLEAR MEDICINE AND BIOLOGY[Internet]. 2014;2(SUPPLEMENT 1):49-49. Available from: https://sid.ir/paper/342059/en

IEEE: Copy

DANG AN BINH, BUI DIEU HANG, TRAN SONG TOAN, TRAN MINH TRI, TRAN VU QUYNH VY, MASSANOBU ISHIGURO, and HIROSHI TOYAMA, “NONINVASIVE REST AND ACETAZOLAMIDE BRAIN PERFUSION ONE – DAY PROTOCOL USING SPECT/CT,” ASIA OCEANIA JOURNAL OF NUCLEAR MEDICINE AND BIOLOGY, vol. 2, no. SUPPLEMENT 1, pp. 49–49, 2014, [Online]. Available: https://sid.ir/paper/342059/en

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