PRODUCTION, FORMULATION AND QUALITY CONTROL OF [13N]NH3 COMPOUND FOR PET IMAGING OF REGIONAL BLOOD FLOW

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JALILIAN A.R.; ROUSHAN FARZAD P.; SABET MAHSA; MIRZAII M.; SARDARI D.; MOAFIAN J.; SATARI A.; ZIAII A.

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Journal: IRANIAN JOURNAL OF NUCLEAR MEDICINE Year:2005 | Volume:- | Issue:23 Page(s): 38-41

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Title

PRODUCTION, FORMULATION AND QUALITY CONTROL OF [13N]NH3 COMPOUND FOR PET IMAGING OF REGIONAL BLOOD FLOW

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Keywords

13NQ2

[13N]NH3Q2

REGIONAL BLOOD FLOWQ2

DE VARDA'S CATALYSTQ2

QUALITY CONTROLQ2

Abstract

In this study, 16O(p,α)13N nuclear reaction was chosen as the best method of N-13 production. High purity natural water targets were bombarded by 18 Me V protons with an intensity of 8td. A production yield of 13.5 mCi/μAh was obtained. Chemical modification of 13N-nitrogen oxides into [13N]NH3 was accomplished using DE VARDA'S CATALYST. Chemical, radiochemical and radionuclide purity controls performed on the final product showed high radiopharmaceutical purity (>98%) in the form of[13N]NH3.[13N]NH3 was formulated in normal saline media at appropriate pH and sterile conditions. Microbial and LAL tests were performed on the final product in order to assure its safety for administration to experimental subjects.

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APA: Copy

JALILIAN, A.R., ROUSHAN FARZAD, P., SABET, MAHSA, MIRZAII, M., SARDARI, D., MOAFIAN, J., SATARI, A., & ZIAII, A.. (2005). PRODUCTION, FORMULATION AND QUALITY CONTROL OF [13N]NH3 COMPOUND FOR PET IMAGING OF REGIONAL BLOOD FLOW. IRANIAN JOURNAL OF NUCLEAR MEDICINE, -(23), 38-41. SID. https://sid.ir/paper/34206/en

Vancouver: Copy

JALILIAN A.R., ROUSHAN FARZAD P., SABET MAHSA, MIRZAII M., SARDARI D., MOAFIAN J., SATARI A., ZIAII A.. PRODUCTION, FORMULATION AND QUALITY CONTROL OF [13N]NH3 COMPOUND FOR PET IMAGING OF REGIONAL BLOOD FLOW. IRANIAN JOURNAL OF NUCLEAR MEDICINE[Internet]. 2005;-(23):38-41. Available from: https://sid.ir/paper/34206/en

IEEE: Copy

A.R. JALILIAN, P. ROUSHAN FARZAD, MAHSA SABET, M. MIRZAII, D. SARDARI, J. MOAFIAN, A. SATARI, and A. ZIAII, “PRODUCTION, FORMULATION AND QUALITY CONTROL OF [13N]NH3 COMPOUND FOR PET IMAGING OF REGIONAL BLOOD FLOW,” IRANIAN JOURNAL OF NUCLEAR MEDICINE, vol. -, no. 23, pp. 38–41, 2005, [Online]. Available: https://sid.ir/paper/34206/en

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