CHANGING THERAPEUTIC PARADIGMS: PREDICTING MCRC LESION RESPONSE TO SELECTIVE INTERNAL RADIONUCLIDE THERAPY (SIRT) BASED ON CRITICAL ABSORBED DOSE THRESHOLDS: A CASE STUDY

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WILLOWSON KATHY P.; BERNARD ELIZABETH J.; MAHER RICHARD; CLARKE STEPHEN J.; BAILEY DALE L.

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Journal Paper

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Journal: Asia Oceania Journal of Nuclear Medicine & Biology Year:2017 | Volume:5 | Issue:1 Page(s): 66-69

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Title

CHANGING THERAPEUTIC PARADIGMS: PREDICTING MCRC LESION RESPONSE TO SELECTIVE INTERNAL RADIONUCLIDE THERAPY (SIRT) BASED ON CRITICAL ABSORBED DOSE THRESHOLDS: A CASE STUDY

Author(s)

Keywords

DOSIMETRY

LIVER

RESPONSE

SIRT

90Y

Abstract

A 65 year old male with metastatic colorectal cancer (mCRC) in the LIVER was referred for selective internal radionuclide therapy (SIRT) following a history of extensive systemic chemotherapy.90Y PET imaging was performed immediately after treatment and used to confirm lesion targeting and measure individual lesion absorbed doses. Lesion DOSIMETRY was highly predictive of eventual RESPONSE in the follow-up FDG PET performed 8 weeks after therapy. The derived radiation dose map was used to plan a second SIRT procedure aiming to protect healthy LIVER by keeping absorbed dose below the critical dose threshold, whilst targeting the remaining lesions that had received sub-critical dosing. Again, 90Y PET was performed immediately post-treatment and used to derive absorbed dose measures to both lesions and healthy parenchyma. Additional follow-up FDG PET imaging again confirmed the role of the 90Y PET dose map as an early predictor of RESPONSE, and a tool for safe repeat treatment planning.

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APA: Copy

WILLOWSON, KATHY P., BERNARD, ELIZABETH J., MAHER, RICHARD, CLARKE, STEPHEN J., & BAILEY, DALE L.. (2017). CHANGING THERAPEUTIC PARADIGMS: PREDICTING MCRC LESION RESPONSE TO SELECTIVE INTERNAL RADIONUCLIDE THERAPY (SIRT) BASED ON CRITICAL ABSORBED DOSE THRESHOLDS: A CASE STUDY. ASIA OCEANIA JOURNAL OF NUCLEAR MEDICINE AND BIOLOGY, 5(1), 66-69. SID. https://sid.ir/paper/342082/en

Vancouver: Copy

WILLOWSON KATHY P., BERNARD ELIZABETH J., MAHER RICHARD, CLARKE STEPHEN J., BAILEY DALE L.. CHANGING THERAPEUTIC PARADIGMS: PREDICTING MCRC LESION RESPONSE TO SELECTIVE INTERNAL RADIONUCLIDE THERAPY (SIRT) BASED ON CRITICAL ABSORBED DOSE THRESHOLDS: A CASE STUDY. ASIA OCEANIA JOURNAL OF NUCLEAR MEDICINE AND BIOLOGY[Internet]. 2017;5(1):66-69. Available from: https://sid.ir/paper/342082/en

IEEE: Copy

KATHY P. WILLOWSON, ELIZABETH J. BERNARD, RICHARD MAHER, STEPHEN J. CLARKE, and DALE L. BAILEY, “CHANGING THERAPEUTIC PARADIGMS: PREDICTING MCRC LESION RESPONSE TO SELECTIVE INTERNAL RADIONUCLIDE THERAPY (SIRT) BASED ON CRITICAL ABSORBED DOSE THRESHOLDS: A CASE STUDY,” ASIA OCEANIA JOURNAL OF NUCLEAR MEDICINE AND BIOLOGY, vol. 5, no. 1, pp. 66–69, 2017, [Online]. Available: https://sid.ir/paper/342082/en

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