THE EFFECT OF VITAMIN D SUPPLEMENTATION ON BLOOD SUGAR AND DIFFERENT INDICES OF INSULIN RESISTANCE IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD)

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FOROUGHI M.; BAYAT CHADEGANI E.; Askari G.; MAGHSOUDI Z.

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Journal: NUTRITION AND FOOD SCIENCES RESEARCH Year:2014 | Volume:1 | Issue:SUPPL. (1) Page(s): 112-112

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Title

THE EFFECT OF VITAMIN D SUPPLEMENTATION ON BLOOD SUGAR AND DIFFERENT INDICES OF INSULIN RESISTANCE IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD)

Author(s)

FOROUGHI M. | BAYAT CHADEGANI E. | Askari G. | MAGHSOUDI Z. | Issue Writer Certificate

Keywords

NON-ALCOHOLIC FATTY LIVER

VITAMIN D

Abstract

Background: Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease in men and women that can progress to advanced cirrhosis or nonalcoholic steatohepatitis (NASH). Insulin resistance is one of pathological causes of nonalcoholic fatty liver. In a number of studies, VITAMIN D supplementation decrease insulin resistance. Therefore, the aim of this study was determined survey to effect of VITAMIN D of supplementation on blood sugar and different indices of insulin resistance in patients with nonalcoholic fatty liver are.Methods: This randomized placebo-controlled clinical trial was conducted in 60 patients with NAFLD. Patients were randomly assigned to receive either VITAMIN D supplements or placebo. Patients in intervention group (n=30) received Perl containing 50, 000 IU VITAMIN D3 (one per week) and those in the placebo group (n=30) received 10 placebo at the same times. Fasting blood samples were taken at baseline and after 10 week of the intervention. Ultrasound was done to diagnose non-alcoholic fatly liver disease diagnose.Results: When the analyses were adjusted for Baseline values, cholecalciferol supplementation resulted in increased serum25 (OH) D concentrations compared to placebo group (+68±12compared to -1.9±2.44nm/L; P: 0.001). Intake of VITAMIN D supplements led to a marginally significant decrease in FBS (fasting blood sugar) (FBS: -12±4 compared to -3±2mg/dL; P, 0.055, HOMA-IR: -1.75±.23 compared to.12±.41; P, 0.066). Serum calcium is increased in intervention group compared to placebo group (4±.4 compared to-3.2±1 mg/dL; P:.032). We did not find any significant effect of VITAMIN D supplementation on serum insulin and HOMA-B levels.Conclusions: VITAMIN D supplementation decreased marginally HOMA-IR and FBS concentration in patients with NAFLD; however VITAMIN D supplementation did not affect on insulin and HOMA-B significantly.

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APA: Copy

FOROUGHI, M., BAYAT CHADEGANI, E., Askari, G., & MAGHSOUDI, Z.. (2014). THE EFFECT OF VITAMIN D SUPPLEMENTATION ON BLOOD SUGAR AND DIFFERENT INDICES OF INSULIN RESISTANCE IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD). NUTRITION AND FOOD SCIENCES RESEARCH, 1(SUPPL. (1)), 112-112. SID. https://sid.ir/paper/342703/en

Vancouver: Copy

FOROUGHI M., BAYAT CHADEGANI E., Askari G., MAGHSOUDI Z.. THE EFFECT OF VITAMIN D SUPPLEMENTATION ON BLOOD SUGAR AND DIFFERENT INDICES OF INSULIN RESISTANCE IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD). NUTRITION AND FOOD SCIENCES RESEARCH[Internet]. 2014;1(SUPPL. (1)):112-112. Available from: https://sid.ir/paper/342703/en

IEEE: Copy

M. FOROUGHI, E. BAYAT CHADEGANI, G. Askari, and Z. MAGHSOUDI, “THE EFFECT OF VITAMIN D SUPPLEMENTATION ON BLOOD SUGAR AND DIFFERENT INDICES OF INSULIN RESISTANCE IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD),” NUTRITION AND FOOD SCIENCES RESEARCH, vol. 1, no. SUPPL. (1), pp. 112–112, 2014, [Online]. Available: https://sid.ir/paper/342703/en

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