Long Non-coding Ribonucleic Acid as a Novel Diagnosis and Prognosis Biomarker of Bladder Cancer (Review Article)

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AFSHAR SAEID; SEYEDABADI SAMAN; SAIDIJAM MASSOUD; Samadi Pouria; Mazaheri laghab Hamzeh; MAHDAVINEZHAD ALI

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Journal Paper

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Journal: Avicenna Journal of Medical Biochemistry Year:2019 | Volume:7 | Issue:1 Page(s): 28-34

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Title

Long Non-coding Ribonucleic Acid as a Novel Diagnosis and Prognosis Biomarker of Bladder Cancer (Review Article)

Author(s)

Keywords

Biomarkers

Long non-coding

RNA

Urinary bladder neoplasm

Abstract

Long non-coding ribonucleic acids (lncRNAs) are the largest group of non-coding RNAs and supposedly have a broad spectrum of diverse functions in normal cellular processes. This study was carried out to review the biological functions of candidate lncRNAs (i. e., H19, MALAT-1, TUG1, UCA-1, MEG-3, HOTAIR, CCAT2, AATBC, and the like) with aberrant expressions that play critical roles in bladder cancer (BC) initiation, progression, and metastasis. A formal narrative review was performed by searching the PubMed database for English articles using a combination of keywords such as “ Long non-coding RNA” , “ lncRNA” , “ cancer” , “ bladder cancer” , “ screening” , “ prognosis” , “ diagnosis” , and “ response to therapy” . In addition, the existing literature was studied on biological function, aberrant expression, and the clinical applications of candidate lncRNAs in BC. By a better understanding of the molecular mechanisms of lncRNAs, they can be used as Biomarkers for tumor signatures in urologic malignancies, which can improve screening, prognosis, diagnosis, and the treatment of BC.

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APA: Copy

AFSHAR, SAEID, SEYEDABADI, SAMAN, SAIDIJAM, MASSOUD, Samadi, Pouria, Mazaheri laghab, Hamzeh, & MAHDAVINEZHAD, ALI. (2019). Long Non-coding Ribonucleic Acid as a Novel Diagnosis and Prognosis Biomarker of Bladder Cancer (Review Article). AVICENNA JOURNAL OF MEDICAL BIOCHEMISTRY, 7(1), 28-34. SID. https://sid.ir/paper/343071/en

Vancouver: Copy

AFSHAR SAEID, SEYEDABADI SAMAN, SAIDIJAM MASSOUD, Samadi Pouria, Mazaheri laghab Hamzeh, MAHDAVINEZHAD ALI. Long Non-coding Ribonucleic Acid as a Novel Diagnosis and Prognosis Biomarker of Bladder Cancer (Review Article). AVICENNA JOURNAL OF MEDICAL BIOCHEMISTRY[Internet]. 2019;7(1):28-34. Available from: https://sid.ir/paper/343071/en

IEEE: Copy

SAEID AFSHAR, SAMAN SEYEDABADI, MASSOUD SAIDIJAM, Pouria Samadi, Hamzeh Mazaheri laghab, and ALI MAHDAVINEZHAD, “Long Non-coding Ribonucleic Acid as a Novel Diagnosis and Prognosis Biomarker of Bladder Cancer (Review Article),” AVICENNA JOURNAL OF MEDICAL BIOCHEMISTRY, vol. 7, no. 1, pp. 28–34, 2019, [Online]. Available: https://sid.ir/paper/343071/en

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