مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

287
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

96
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

THE ANTI-PROLIFERATIVE AND ANTI-ANGIOGENIC EFFECT OF THE METHANOL EXTRACT FROM BRITTLE STAR

Pages

  0-0

Abstract

 Background: Anti-angiogenic therapy is a crucial step in cancer treatment. The discovery of new anti-angiogenic compounds from MARINE ORGANISMS has become an attractive concept in anti-cancer therapy. Because little data correlated to the pro- and anti-angiogenic efficacies of Ophiuroidea, which include BRITTLE STAR, the current study was designed to explore the anti-angiogenic potential of BRITTLE STAR methanol extract in vitro and in vivo.Methods: The ANTI-PROLIFERATIVE effect of BRITTLE STAR extract on A2780cp cells was examined by MTT assays, and transcriptional expression of VEGF and b-FGF was evaluated by RT-PCR. In an in vivo model, 40 fertilized Ross eggs were divided into control and three experimental groups. The experimental groups were incubated with BRITTLE STAR extract at concentrations of 25, 50 and 100 mg/ml, and photographed by photo-stereomicroscopy. Ultimately, numbers and lengths of vessels were measured by Image J software. Data were analyzed with SPSS software (p<0.05).Results: Results illustrated that the BRITTLE STAR extract exerted a dose- and time-dependent ANTI-PROLIFERATIVE effect on A2780cp cancer cells. In addition, VEGF and b-FGF expression decreased with BRITTLE STAR methanol extract treatment. Macroscopic evaluations revealed significant changes in the second and third experimental group compared to controls (p<0.05).Conclusion: These finding revealed the anti-angiogenic effects of BRITTLE STAR methanol extract in vitro and in vivo confer novel insight into the application of natural marine products in ANGIOGENESIS-related pathologies.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    BAHARARA, JAVAD, AMINI, ELAHEH, & MOUSAVI, MARZIEH. (2015). THE ANTI-PROLIFERATIVE AND ANTI-ANGIOGENIC EFFECT OF THE METHANOL EXTRACT FROM BRITTLE STAR. REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, 3(2), 0-0. SID. https://sid.ir/paper/343107/en

    Vancouver: Copy

    BAHARARA JAVAD, AMINI ELAHEH, MOUSAVI MARZIEH. THE ANTI-PROLIFERATIVE AND ANTI-ANGIOGENIC EFFECT OF THE METHANOL EXTRACT FROM BRITTLE STAR. REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY[Internet]. 2015;3(2):0-0. Available from: https://sid.ir/paper/343107/en

    IEEE: Copy

    JAVAD BAHARARA, ELAHEH AMINI, and MARZIEH MOUSAVI, “THE ANTI-PROLIFERATIVE AND ANTI-ANGIOGENIC EFFECT OF THE METHANOL EXTRACT FROM BRITTLE STAR,” REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 3, no. 2, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/343107/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button