مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

TRANSFORMING GROWTH FACTOR BETA 1 869T/C AND 915G/C POLYMORPHISMS AND RISK OF AUTISM SPECTRUM DISORDERS

Pages

  0-0

Abstract

 Background: Transforming growth factor-b1 (TGF-b1) has been found to play a crucial role in early central nervous system DEVELOPMENT. Several studies have illustrated decreased TGF- b1 levels in sera and brains of autistic children. Two point mutations in the TGF- b1 signal peptide at 869T/C and 915G/C have been reported to influence TGF-b1 expression. The aim of the present study was to investigate the correlation of TGF-b1 POLYMORPHISMs and their haplotypes with autism.Methods: This study was performed on 39 autistic patients and 35 age- and sex-matched normal controls in an Iranian population, using the sequence specific primed-polymerase chain reaction (PCR-SSP) technique. Patients were divided into mild-to-moderate and severe groups according to the childhood autism rating scale.Results: No significant differences were observed for allele, genotype, or haplotype frequencies between the autistics and controls. Only a slight difference was observed in GC25 between the controls and all children with autism.Conclusion: Thus, these results indicate that the POLYMORPHISMs in TGF- b1 gene may not play an important role in the DEVELOPMENT of autism.

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    APA: Copy

    KHAKZAD, MOHAMMAD REZA, SALARI, FARHAD, JAVANBAKHT, MARYAM, MARYAM, HOJATI, VARASTEH, ABDOLREZA, SANKIAN, MOJTABA, & MESHKAT, MOJTABA. (2015). TRANSFORMING GROWTH FACTOR BETA 1 869T/C AND 915G/C POLYMORPHISMS AND RISK OF AUTISM SPECTRUM DISORDERS. REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, 3(2), 0-0. SID. https://sid.ir/paper/343108/en

    Vancouver: Copy

    KHAKZAD MOHAMMAD REZA, SALARI FARHAD, JAVANBAKHT MARYAM, MARYAM HOJATI, VARASTEH ABDOLREZA, SANKIAN MOJTABA, MESHKAT MOJTABA. TRANSFORMING GROWTH FACTOR BETA 1 869T/C AND 915G/C POLYMORPHISMS AND RISK OF AUTISM SPECTRUM DISORDERS. REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY[Internet]. 2015;3(2):0-0. Available from: https://sid.ir/paper/343108/en

    IEEE: Copy

    MOHAMMAD REZA KHAKZAD, FARHAD SALARI, MARYAM JAVANBAKHT, HOJATI MARYAM, ABDOLREZA VARASTEH, MOJTABA SANKIAN, and MOJTABA MESHKAT, “TRANSFORMING GROWTH FACTOR BETA 1 869T/C AND 915G/C POLYMORPHISMS AND RISK OF AUTISM SPECTRUM DISORDERS,” REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 3, no. 2, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/343108/en

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